Evidence map›Paper›PMID 36444224›Full record

ArticleJACC. CardioOncology2022

Optimal Timing of a Physical Exercise Intervention to Improve Cardiorespiratory Fitness: During or After Chemotherapy.

Gabriela G F van der Schoot, Harm L Ormel, Nico-Derk L Westerink, Anne M May, Sjoerd G Elias, Yoran M Hummel, Joop D Lefrandt, Peter van der Meer, Joost P van Melle, Boelo J Poppema and 9 more

2 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. CardioOncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 32 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 3 pooled it
4.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06672120 narecruitingnot on this mapstarted 2025, after this paper: background citation

Exercise in Regional Breast Cancer With Neoadjuvant Anthracycline- Based Chemotherapy and Immunotherapy With Checkpoint-Inhibition

TypeinterventionalSponsorTechnical University of MunichRan2025 to 2028Enrolled120ConditionsCancer, BreastArmsExercise training
NCT07502963 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Effectiveness of a Multimodal Outpatient Supervised Physical Activity Program to Improve Tolerance and Efficacy of Chemotherapy in Adults With Breast, Lung and Colon Cancer: Randomized Clinical Trial.

TypeinterventionalSponsorUniversity of Vic - Central University of CataloniaRan2026 to 2027Enrolled70ConditionsBreast Cancer, Lung Cancer (Non-Small Cell), Colorectal Cancer, Physical ActivityArmsPREDU Exercise Program, Recommendation Exercise Program
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 49 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 1 country.

Gabriela G F van der SchootDepartment of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Harm L OrmelDepartment of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Nico-Derk L WesterinkDepartment of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Anne M MayJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Sjoerd G EliasJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Yoran M HummelDepartment of Pulmonary Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Joop D LefrandtDepartment of Vascular Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Peter van der MeerDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Joost P van MelleDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Boelo J PoppemaDepartment of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Joyce M A StelDepartment of Rehabilitation Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Annette W G van der VeldenDepartment of Internal Medicine, Martini Hospital Groningen, Groningen, the Netherlands.
Aline H VrielingDepartment of Rehabilitation Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Johan B WempeDepartment of Pulmonary Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Marcel G Ten WoldeDepartment of Rehabilitation Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Marcel NijlandDepartment of Hematology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Elisabeth G E de VriesDepartment of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Jourik A GietemaDepartment of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Annemiek M E WalenkampDepartment of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
University Medical Center Groningen · NLUniversity of Groningen · NLMartini Ziekenhuis · NLUniversity Medical Center Utrecht · NLUtrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Despite the widely acknowledged benefit of exercise for patients with cancer, little evidence on the optimal timing of exercise on adverse effects of cancer treatment is available. Objectives: The aim of this study was to determine whether an exercise intervention initiated during chemotherapy is superior to an intervention initiated after chemotherapy for improving long-term cardiorespiratory fitness (peak oxygen uptake [VO Methods: In this prospective, randomized clinical trial, patients scheduled to receive curative chemotherapy were randomized to a 24-week exercise intervention, initiated either during chemotherapy (group A) or afterward (group B). The primary endpoint was VO Results: A total of 266 patients with breast (n = 139), testicular (n = 95), and colon cancer (n = 30) as well as lymphoma (n = 2) were included. VO Conclusions: Exercise can be safely performed during chemotherapy and prevents fatigue and decreases in VO

Indexed as

cardiorespiratory fitnesschemotherapyfatigueHIIT, high-intensity interval trainingHRQoL, health-related quality of lifeMET-h, the amount of kcal burnt per kilogram body weight per hourmuscle strengthPASE, Physical Activity Scale for the Elderlyphysical exercisequality of lifeSAE, serious adverse event(s)UMCG, University Medical Center GroningenVO2peak, peak oxygen uptake

Identifiers

PMID36444224
PMCPMC9700259
OpenAlexW4306722636

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.