Evidence map›Paper›PMID 36444158›Full record

ArticlePsychiatry investigation2022

The Effect of Temperament on the Association Between Pre-treatment Anxiety and Chemotherapy-Related Symptoms in Patients With Breast Cancer.

Jung-In Choi, Sanghyup Jung, Gyu Han Oh, Kyung-Lak Son, Kwang-Min Lee, Dooyoung Jung, Tae-Yong Kim, Seock-Ah Im, Kyung-Hun Lee, Min-Sup Shin and 2 more

Open access · diamondAbstract read
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In one paragraph

Article in Psychiatry investigation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Jung-In ChoiDepartment of Clinical Medical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.
Sanghyup JungDepartment of Psychiatry, National Rehabilitation Center, Seoul, Republic of Korea.
Gyu Han OhPublic Health Medical Service, Seoul National University Hospital, Seoul, Republic of Korea.
Kyung-Lak SonDepartment of Psychiatry, Dongguk University Ilsan Hospital, Goyang, Republic of Korea.
Kwang-Min LeeMind Lab the Place, Seoul, Republic of Korea.
Dooyoung JungDepartment of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea.
Tae-Yong KimDepartment of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Seock-Ah ImDepartment of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Kyung-Hun LeeDepartment of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Min-Sup ShinDepartment of Psychiatry and Behavioral Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.
Bong-Jin HahmDepartment of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea.
Chan-Woo YeomDepartment of Psychiatry, Uijeongbu Eulji Medical Center, Eulji University School of Medicine, Uijeongbu, Republic of Korea.
Seoul National University · KRDongguk University Ilsan Hospital · KREulji University · KRSeoul National University Hospital · KRUlsan National Institute of Science and Technology · KR

Funding

Ministry of EducationNational Research Foundation of Korea 2013R1A1A2013480National Research Foundation of Korea 2019R1A2C1003675
6 · The paper itself

Abstract

objectivePre-treatment anxiety (PA) before chemotherapy increases complaints of chemotherapy-related symptoms (CRS). The results on the association have been inconsistent, and the effect of temperament remains unclear. We aimed to determine whether PA is a risk factor for CRS and the effect of differing temperaments on CRS.

methodsThis prospective study comprised 176 breast cancer patients awaiting adjuvant chemotherapy post-surgery. We assessed CRS, PA, and temperament using the MD Anderson Symptom Inventory (MDASI), the Hospital Anxiety and Depression Scale, and the short form of the Temperament and Character Inventory-Revised, respectively. The MDASI was re-administered three weeks after the first chemo-cycle.

resultsPA showed weak positive correlation with several CRS after the first cycle; no CRS was significantly associated with PA when pre-treatment depressive symptoms and baseline CRS were adjusted in multiple regression analysis. Moderation model analysis indicated that the PA effect on several CRS, including pain, insomnia, anorexia, dry mouth, and vomiting, was moderated by harm avoidance (HA) but not by other temperament dimensions. In particular, PA was positively associated with CRS in patients with low HA.

conclusionThe results in patients with low HA indicate that more attention to PA in patients with confident and optimistic temperaments is necessary.

Indexed as

AnxietyBreast cancerChemotherapy-related symptomsHarm avoidanceTemperament

Identifiers

PMID36444158
PMCPMC9708865
OpenAlexW4310093777

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.