ArticleClinical epigenetics2022
An examination of mediation by DNA methylation on birthweight differences induced by assisted reproductive technologies.
Article in Clinical epigenetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 8 citations in OpenAlex.
- The length of the embryo culture in assisted reproductive technology does not have a major impact on newborn DNA methylation.Bioscience reports · 2026Article
- Factors influencing the birth weight of ART-conceived offspring.Journal of assisted reproduction and genetics · 2025Review
- Sex differences in childhood cancer risk following ART conception: a registry-based study.Human reproduction (Oxford, England) · 2025Article
- Obstetrical and neonatal outcomes after vitrified-warmed blastocyst transfer in day 1 rescue intracytoplasmic sperm injection cycles: a retrospective cohort study.Journal of assisted reproduction and genetics · 2024Article
- [Exploring the Role of PCDHGB4 in the Occurrence of Lung Squamous Cell Carcinoma Based on Bioinformatics Analysis].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2024Article
- Overweight or obesity in children born after assisted reproductive technologies in Denmark: A population-based cohort study.PLoS medicine · 2023Article
- Epigenetic clocks and female fertility timeline: A new approach to an old issue?Frontiers in cell and developmental biology · 2023Review
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChildren born after assisted reproductive technologies (ART) differ in birthweight from those naturally conceived. It has been hypothesized that this might be explained by epigenetic mechanisms. We examined whether cord blood DNA methylation mediated the birthweight difference between 890 newborns conceived by ART (764 by fresh embryo transfer and 126 frozen thawed embryo transfer) and 983 naturally conceived newborns from the Norwegian Mother, Father, and Child Cohort Study (MoBa). DNA methylation was measured by the Illumina Infinium MethylationEPIC array. We conducted mediation analyses to assess whether differentially methylated CpGs mediated the differences in birthweight observed between: (1) fresh embryo transfer and natural conception and (2) frozen and fresh embryo transfer.
resultsWe observed a difference in birthweight between fresh embryo transfer and naturally conceived offspring of - 120 g. 44% (95% confidence interval [CI] 26% to 81%) of this difference in birthweight between fresh embryo transfer and naturally conceived offspring was explained by differences in methylation levels at four CpGs near LOXL1, CDH20, and DRC1. DNA methylation differences at two CpGs near PTGS1 and RASGRP4 jointly mediated 22% (95% CI 8.1% to 50.3%) of the birthweight differences between fresh and frozen embryo transfer.
conclusionOur findings suggest that DNA methylation is an important mechanism in explaining birthweight differences according to the mode of conception. Further research should examine how gene regulation at these loci influences fetal growth.
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