Evidence map›Paper›PMID 36443737›Full record

Trial reportBMC neurology2022

TURN-IT: a novel turning intervention program to improve quality of turning in daily life in people with Parkinson's disease.

L A King, P Carlson-Kuhta, J L Wilhelm, J A Lapidus, M L Dale, L S Talman, N Barlow, M Mancini, F B Horak

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in BMC neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04897256 (Mobility in Daily Life and Falls in Parkinson's Disease), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04897256 naactive not recruitingnot on this map

Mobility in Daily Life and Falls in Parkinson's Disease: Potential for Rehabilitation

TypeinterventionalSponsorOregon Health and Science UniversityRan2021 to 2026Enrolled55ConditionsParkinson DiseaseArmsTURN-IT exercise program
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

L A KingDepartment of Neurology, Oregon Health & Science University, Portland, OR, USA. kingla@ohsu.edu.ORCID http://orcid.org/0000-0001-9802-4446
P Carlson-KuhtaDepartment of Neurology, Oregon Health & Science University, Portland, OR, USA.
J L WilhelmDepartment of Neurology, Oregon Health & Science University, Portland, OR, USA.
J A LapidusSchool of Public Health, Oregon Health & Science University, Portland State University, Portland, OR, USA.
M L DaleDepartment of Neurology, Oregon Health & Science University, Portland, OR, USA.
L S TalmanDepartment of Neurology, Oregon Health & Science University, Portland, OR, USA.
N BarlowDepartment of Neurology, Oregon Health & Science University, Portland, OR, USA.
M ManciniDepartment of Neurology, Oregon Health & Science University, Portland, OR, USA.
F B HorakDepartment of Neurology, Oregon Health & Science University, Portland, OR, USA.
Oregon Health & Science University · USPortland State University · US

Funding

Oregon Clinical and Translational Research Institute - The National COVID Cohort Collaborative (N3C)UL1TR002369 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Cynthia D Morris, Christopher G. Slatore · 2017 to 2026
$78.4M
Techniques DevelopmentP2CHD086844 · NICHD · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI THOMPSON, AIKO · 2015 to 2024
$12.7M
Mobility in Daily Life and Falls in Parkinson's Disease: Potential for RehabilitationR01HD100383 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI HORAK, FAY BAHLING, MANCINI, MARTINA · 2020 to 2024
$2.6M
NCATS NIH HHS UL1 TR002369NICHD NIH HHS P2C HD086844NICHD NIH HHS R01 HD100383NIH HHS R01 HD100383
6 · The paper itself

Abstract

backgroundPeople with Parkinson's disease (PD) have a high fall rate and many falls are associated with turns. Despite this, there is minimal research on effects of rehabilitation on the quality of turns. Further, quantifying turns in the home may have broader implications since rehabilitation of turns would ideally improve turning in real world mobility.

methodsSixty people with PD and a history of falls will be randomized to receive either a novel TURNing InTervention (TURN-IT) or no intervention (control group). The TURN-IT group will be seen for 6 weeks (18 visits) for an individualized, progressive program that is based on the specific constraints of turning in PD. Wearable sensors will be used to measure 7 days of mobility, including turns, before and after intervention or control period. In addition, blinded assessments of gait, mobility and turns will occur before and after intervention for both groups and falls will be monitored for twelve months post intervention with bimonthly email questionnaires. DISCUSSION: This study has the potential to change how we rehabilitate and assess turning in people with PD and falls. There are several novel aspects to our study including a comprehensive turning-focused intervention that is tailored to the underlying constraints that impair turning in people with PD. Further, our outcome measure of turning quality during 7 days of daily life is novel and has implications for determining real-life changes after rehabilitation. The ultimate goal of this rehabilitation intervention is to improve how patients turn in daily life and to reduce falls. TRIALS REGISTRATION: This protocol is registered at clinicaltrials.gov; #NCT04897256; https://clinicaltrials.gov/ct2/show/NCT04897256?term=Horak&cond=Parkinson+Disease&draw=2&rank=4 .

Indexed as

Parkinson DiseaseGaitHumansFallsInertial sensorsParkinson diseasePhysical rehabilitationTurning

Identifiers

PMID36443737
PMCPMC9703770
OpenAlexW4310211441

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.