ArticlePrenatal diagnosis2023
Termination of pregnancy after a prenatal diagnosis of congenital diaphragmatic hernia: Factors influencing the parental decision process.
Article in Prenatal diagnosis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Repeated Treatments With Extracorporeal Membrane Oxygenation in Congenital Diaphragmatic Hernia Patients: A Registry Analysis.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2026Article
- Pulmonary T2* quantification of fetuses with congenital diaphragmatic hernia: a retrospective, case-controlled, MRI pilot study.Pediatric research · 2026Article
- The factors influencing parents and clinicians in medical decision making for fetuses with congenital diaphragmatic hernia at a tertiary referral centre in Beijing: a five-year retrospective study.BMC pregnancy and childbirth · 2026Article
- Organization of care of infants with congenital diaphragmatic hernia-Building a high-functioning CDH program.Journal of perinatology : official journal of the California Perinatal Association · 2024Review
- Review of the Evaluation of Pulmonary Hypoplasia as an Important Determinant of Clinical Outcomes in Infants with Congenital Diaphragmatic Hernia.Medical science monitor : international medical journal of experimental and clinical research · 2024Review
- Article
- Termination of pregnancy after a prenatal diagnosis of congenital diaphragmatic hernia: Factors influencing the parental decision process.Prenatal diagnosis · 2023Article
- Editorial: Unsolved problems in congenital diaphragmatic hernia.Frontiers in pediatrics · 2023Article
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Authors and funding
7 authors.
Funding
Abstract
objectiveTo evaluate the incidence of termination of pregnancies (TOP) and factors associated with the decision for TOP in prenatally detected congenital diaphragmatic hernia (CDH). STUDY
designSingle-centre retrospective cohort includes all prenatally detected CDH cases born between January 2009 and December 2021. Parental factors, such as parity, and fetal characteristics, such as disease severity, were collected. Descriptive statistics were used to present the data. Differences between terminated and continued pregnancies were analysed.
resultsThe study population consisted of 278 prenatally detected CDH cases of which 80% detected <24 weeks of gestation. The TOP rate was 28% in cases that were detected <24 weeks of gestation. Twenty continued pregnancies resulted in either intrauterine fetal demise (n = 6), preterm birth <24 weeks (n = 2), or comfort care after birth (n = 12). The survival rate was 70% in the remaining 195 live born cases. Factors associated with the decision for TOP were additional fetal genetic or anatomical abnormalities (p < 0.0001) and expected severity of pulmonary hypoplasia in left-sided CDH (p = 0.0456).
conclusionThe decision to terminate a pregnancy complicated by fetal CDH depends on the severity of pulmonary hypoplasia and the presence of additional abnormalities. This emphasises the importance of early referral to expertise centres for detailed evaluation and multidisciplinary counselling.
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