Evidence map›Paper›PMID 36443486›Full record

ArticleNature methods2022

A large-scale neural network training framework for generalized estimation of single-trial population dynamics.

Mohammad Reza Keshtkaran, Andrew R Sedler, Raeed H Chowdhury, Raghav Tandon, Diya Basrai, Sarah L Nguyen, Hansem Sohn, Mehrdad Jazayeri, Lee E Miller, Chethan Pandarinath

Abstract read
In one paragraph

Article in Nature methods, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed.

  1. Article
  2. Meta-learning is expressed through altered prefrontal cortical dynamics.bioRxiv : the preprint server for biology · 2026
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  12. Improved inference of latent neural states from calcium imaging data.bioRxiv : the preprint server for biology · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mohammad Reza Keshtkaran *Wallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, USA.
Andrew R Sedler *Wallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, USA.ORCID http://orcid.org/0000-0001-9480-0698
Raeed H ChowdhuryDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, USA.ORCID http://orcid.org/0000-0002-5934-919X
Raghav TandonWallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, USA.ORCID http://orcid.org/0000-0003-2603-4930
Diya BasraiWallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, USA.
Sarah L NguyenCollege of Computing, Georgia Institute of Technology, Atlanta, GA, USA.
Hansem SohnDepartment of Brain and Cognitive Sciences, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-8593-7473
Mehrdad JazayeriDepartment of Brain and Cognitive Sciences, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Lee E MillerDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, USA.ORCID http://orcid.org/0000-0001-8675-7140
Chethan PandarinathWallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, USA. chethan@gatech.edu.ORCID http://orcid.org/0000-0003-1241-1432

Funding

Interdisciplinary Engineering Career Development Center in Movement and Rehabilitation SciencesK12HD073945 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DEWALD, JULIUS P, REINKENSMEYER, DAVID JAY · 2012 to 2021
$7.9M
Primate model of an intracortically controlled FES prostR01NS053603 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KENNEDY, ANN KATHRYN, MILLER, LEE · 2006 to 2021
$7.1M
Biomimetic Somatosensory Feedback through IntracorticalmicrostimulationR01NS095251 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BENSMAIA, SLIMAN, GRILL, WARREN M. · 2016 to 2020
$3.7M
Fusing motor neuroscience and artificial intelligence to create next-generation neural prostheses.DP2NS127291 · NINDS · EMORY UNIVERSITY · PI PANDARINATH, CHETHAN · 2021 to 2024
$2.4M
Neural mechanisms of timing in the oculomotor systemR01NS078127 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI JAZAYERI, MEHRDAD · 2014 to 2018
$1.7M
Robust modeling of within- and across-area population dynamics using recurrent neural networks - Admin SupplRF1DA055667 · NIDA · EMORY UNIVERSITY · PI MILLER, LEE, PANDARINATH, CHETHAN · 2021 to 2023
$1.6M
Sensorimotor Learning Through Adjustments of Cortical DynamicsR01NS119519 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI JAZAYERI, MEHRDAD · 2021 to 2024
$1.5M
NICHD NIH HHS K12 HD073945NIDA NIH HHS RF1 DA055667NINDS NIH HHS DP2 NS127291NINDS NIH HHS R01 NS053603NINDS NIH HHS R01 NS078127NINDS NIH HHS R01 NS095251NINDS NIH HHS R01 NS119519
6 · The paper itself

Abstract

Achieving state-of-the-art performance with deep neural population dynamics models requires extensive hyperparameter tuning for each dataset. AutoLFADS is a model-tuning framework that automatically produces high-performing autoencoding models on data from a variety of brain areas and tasks, without behavioral or task information. We demonstrate its broad applicability on several rhesus macaque datasets: from motor cortex during free-paced reaching, somatosensory cortex during reaching with perturbations, and dorsomedial frontal cortex during a cognitive timing task.

Indexed as

Motor CortexNeural Networks, ComputerAnimalsMacaca mulattaPopulation DynamicsSomatosensory Cortex

Identifiers

PMID36443486
PMCPMC9825111

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.