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ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2023

Mortality of central nervous system tumors in pediatric patients of Brazil from 1979 to 2019.

Bruno Pellozo Cerqueira, Jayane Mendes, Luma Carvalho, Pedro Arthur Moreira Aredes, Rhuann Pontes Dos Santos Silva, Edna E Gouveia, Felipe Câncio Nascimento, Adilson J M de Oliveira

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Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Pediatric neurocritical care and neuro-oncology in Brazil: ten-year experience at a reference unit.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026
    Observational
  2. Long-term epidemiological trends in (primary) pediatric central nervous system tumors: a 25-year cohort analysis in Western Mexico.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025
    Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bruno Pellozo CerqueiraFederal University of São Paulo, São Paulo, Brazil.
Jayane MendesUnirG University, Tocantins, Brazil.
Luma CarvalhoUnirG University, Tocantins, Brazil.
Pedro Arthur Moreira AredesFederal University of Juiz de Fora, Juiz de Fora, Brazil.
Rhuann Pontes Dos Santos SilvaCatholic University of Pernambuco, Recife, Brazil. rhuannpontes02@gmail.com.ORCID 0000-0002-2126-6655
Edna E GouveiaAmerican University of the Caribbean School of Medicine, St. Maarten, Netherlands Antilles.
Felipe Câncio NascimentoState University of Ponta Grossa, Paraná, Brazil.
Adilson J M de OliveiraNeurosurgery Department, Neuroscience Center, Clinica Girassol, Luanda, Angola.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeCancer is the second leading cause of death in children from 2001 to 2005 in Brazil. This study aimed to describe the pattern of mortality from central nervous system (CNS) tumors in children in Brazil from 1979 to 2019.

methodsA descriptive study was carried out using data from the Mortality Information System (SIM) of the Ministry of Health, according to the International Classification of Diseases (ICD-9 and ICD-10), between 1979 and 2019. The frequencies of the distribution of available variables were calculated: age (0 - 19 years), s skin color, tumor behavior, year and place of death (by region), ICD-10, and all of these, excluding skin color (by ICD-9). Mortality rates in general, mortality from neoplasms, and specific rates of CNS tumors were calculated considering the variables described above.

resultsIn 40 years (1979 - 2019), there were 21,940 deaths due to brain tumors in children. A different pattern of the mortality rate of brain tumors was shown in children per age (increasing until age 5 - 9 years (28.9%) and then decreasing until age 15 - 19 years (20.2%)). The Southeast (44.3%), Northeast (23.4%), and South (17.5%) regions of Brazil had the highest rates; 94.7% of tumors were malignant, and 91.1% of deaths were observed in hospitals.

conclusionTo our knowledge, this is the first description of the mortality rate epidemiology of brain/CNS tumors in children in Brazil over 40 years. Furthermore, tumor malignancy, hospitals, and the Southeast and Northeast region of Brazil are factors associated with a higher mortality rate.

Indexed as

Brain NeoplasmsCentral Nervous System NeoplasmsAdolescentAdultBrazilChildChild, PreschoolHumansInfantInfant, NewbornYoung AdultEpidemiologyNeuro-oncologyNeurosurgeryPediatric Neurosurgery

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.