Evidence map›Paper›PMID 36443371›Full record

ArticleScientific reports2022

Association of right precuneus compression with apathy in idiopathic normal pressure hydrocephalus: a pilot study.

Yoshihiro Chadani, Tetsuo Kashibayashi, Takahiro Yamamoto, Atsushi Tsuda, Ryoko Fujito, Masanori Akamatsu, Naoto Kamimura, Ryuichi Takahashi, Takuji Yamagami, Hirokazu Furuya and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Yoshihiro ChadaniDepartment of Neuropsychiatry, Kochi Medical School, Kochi University, Kohasu Oko-Cho, Nankoku, Kochi, 783-8505, Japan.
Tetsuo KashibayashiDepartment of Neuropsychiatry, Kochi Medical School, Kochi University, Kohasu Oko-Cho, Nankoku, Kochi, 783-8505, Japan.
Takahiro YamamotoDepartment of Rehabilitation, Kochi Medical School, Kochi University, Kohasu Oko-Cho, Nankoku, Kochi, Japan.
Atsushi TsudaDepartment of Neuropsychiatry, Kochi Medical School, Kochi University, Kohasu Oko-Cho, Nankoku, Kochi, 783-8505, Japan.
Ryoko FujitoDepartment of Neuropsychiatry, Kochi Medical School, Kochi University, Kohasu Oko-Cho, Nankoku, Kochi, 783-8505, Japan.
Masanori AkamatsuDepartment of Neuropsychiatry, Kochi Medical School, Kochi University, Kohasu Oko-Cho, Nankoku, Kochi, 783-8505, Japan.
Naoto KamimuraDepartment of Neuropsychiatry, Kochi Medical School, Kochi University, Kohasu Oko-Cho, Nankoku, Kochi, 783-8505, Japan.
Ryuichi TakahashiDementia-Related Disease Medical Center, Departments of Neurology and Cognitive Disorders, Hyogo Prefectural Rehabilitation Hospital at Nishi-Harima, Tatsuno, Hyogo, Japan.
Takuji YamagamiDepartment of Diagnostic and Interventional Radiology, Kochi Medical School, Kochi University, Kohasu Oko-Cho, Nankoku, Kochi, Japan.
Hirokazu FuruyaDepartment of Neurology, Kochi Medical School, Kochi University, Kohasu Oko-Cho, Nankoku, Kochi, Japan.
Tetsuya UebaDepartment of Neurosurgery, Kochi Medical School, Kochi University, Kohasu Oko-Cho, Nankoku, Kochi, Japan.
Motoaki SaitoDepartment of Pharmacology, Kochi Medical School, Kochi University, Kohasu Oko-Cho, Nankoku, Kochi, Japan.
Keiji InoueDepartment of Urology, Kochi Medical School, Kochi University, Kohasu Oko-Cho, Nankoku, Kochi, Japan.
Hiroaki KazuiDepartment of Neuropsychiatry, Kochi Medical School, Kochi University, Kohasu Oko-Cho, Nankoku, Kochi, 783-8505, Japan. kazui@kochi-u.ac.jp.
Kōchi University · JPHimeji Medical Center · JPHyogo Social Welfare Corporation · JP

Funding

Japan Society for the Promotion of Science JP19H03585MHLW Research on Dementia Program JP22GB1002
6 · The paper itself

Abstract

Apathy is frequently observed in idiopathic normal pressure hydrocephalus (iNPH) and worsens cognitive impairment and gait disturbance. In this study, we evaluated the regions associated with apathy in iNPH using statistical imaging analysis on the whole brain, both in terms of cerebral blood flow and gray matter volume. Twenty-seven patients with iNPH were assigned to two groups based on their scores on the neuropsychiatric inventory items related to apathy; 18 patients were assigned to the group with apathy (iNPH + APA) and 9 to the group without apathy (iNPH - APA). The magnetic resonance images and cerebral blood flow single-photon emission computed tomography data of the two groups were compared using statistical parametric mapping 12. The regional gray matter volume of the right precuneus was significantly larger in the iNPH + APA group than in the iNPH - APA group, but the regional cerebral blood flow in any region of the brain was not significantly different between the two groups. These results suggested that the larger gray matter volume, which is thought to reflect gray matter compression, in the precuneus might be involved in apathy in iNPH.

Indexed as

ApathyData CompressionHydrocephalus, Normal PressureHumansParietal LobePilot Projects

Identifiers

PMID36443371
PMCPMC9705315
OpenAlexW4310193589

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.