Evidence map›Paper›PMID 36443351›Full record

ArticleScientific reports2022

Safety and efficacy of human polymerized hemoglobin on guinea pig resuscitation from hemorrhagic shock.

Cynthia R Muller, Alexander T Williams, Cynthia Walser, Allyn M Eaker, Jose Luis Sandoval, Clayton T Cuddington, Savannah R Wolfe, Andre F Palmer, Pedro Cabrales

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Hemoglobin-based oxygen carriers with antioxidant properties.Journal of materials chemistry. B · 2026
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  8. Polymerized human hemoglobin with low and high oxygen affinity in trauma models.Translational research : the journal of laboratory and clinical medicine · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Cynthia R MullerDepartment of Bioengineering, University of California, 0412, 9500 Gilman Dr. La Jolla, San Diego, CA, 92093-0412, USA.
Alexander T WilliamsDepartment of Bioengineering, University of California, 0412, 9500 Gilman Dr. La Jolla, San Diego, CA, 92093-0412, USA.
Cynthia WalserDepartment of Bioengineering, University of California, 0412, 9500 Gilman Dr. La Jolla, San Diego, CA, 92093-0412, USA.
Allyn M EakerDepartment of Bioengineering, University of California, 0412, 9500 Gilman Dr. La Jolla, San Diego, CA, 92093-0412, USA.
Jose Luis SandovalDepartment of Bioengineering, University of California, 0412, 9500 Gilman Dr. La Jolla, San Diego, CA, 92093-0412, USA.
Clayton T CuddingtonWilliam G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH, USA.
Savannah R WolfeWilliam G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH, USA.
Andre F PalmerWilliam G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH, USA.
Pedro CabralesDepartment of Bioengineering, University of California, 0412, 9500 Gilman Dr. La Jolla, San Diego, CA, 92093-0412, USA. pcabrales@ucsd.edu.
University of California, San Diego · USThe Ohio State University · US

Funding

PEGylated megahemoglobin for use as a red blood cell substituteR01HL138116 · NHLBI · OHIO STATE UNIVERSITY · PI CABRALES, PEDRO, KAUMAYA, PRAVIN T. P. · 2017 to 2020
$2.9M
Attenuating the Oxidative and Myocardial Side-Effects of Acellular HemoglobinR01HL126945 · NHLBI · OHIO STATE UNIVERSITY · PI CABRALES, PEDRO, PALMER, ANDRE FRANCIS · 2016 to 2019
$1.7M
Polymerized Hemoglobins for Facilitated Oxygen Transport in Hepatic BioreactorsR01EB021926 · NIBIB · OHIO STATE UNIVERSITY · PI BERTHIAUME, FRANCOIS, PALMER, ANDRE FRANCIS · 2016 to 2019
$1.4M
NHLBI NIH HHS R01 HL126945NHLBI NIH HHS R01 HL138116NIBIB NIH HHS R01 EB021926
6 · The paper itself

Abstract

For the past thirty years, hemoglobin-based oxygen carriers (HBOCs) have been under development as a red blood cell substitute. Side-effects such as vasoconstriction, oxidative injury, and cardiac toxicity have prevented clinical approval of HBOCs. Recently, high molecular weight (MW) polymerized human hemoglobin (PolyhHb) has shown positive results in rats. Studies have demonstrated that high MW PolyhHb increased O

Indexed as

Blood SubstitutesShock, HemorrhagicAnimalsGuinea PigsHumansInflammationOxygenPolymerizationRatsResuscitationBlood SubstitutesOxygen

Identifiers

PMID36443351
PMCPMC9703428
OpenAlexW4310172050

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.