ArticleNature communications2022
Paired electrolysis-enabled nickel-catalyzed enantioselective reductive cross-coupling between α-chloroesters and aryl bromides.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Capture and identification of the electrogenerated picosecond intermediates by mass spectrometry.Fundamental research · 2026Article
- Recent Advancements in Nickel-Catalyzed Electrochemical Reductive Cross-Coupling.ACS organic & inorganic Au · 2025Review
- Electrochemical Synergistic Ni/Co-Catalyzed Carbonylative Cross-Electrophile Coupling of Aryl and Alkyl Halides with CO.JACS Au · 2025Article
- Enantioselective reductive cross-couplings to forge C(spNature communications · 2025Article
- Electrochemical Enantioselective Nickel-Catalyzed Cross-Coupling of Aldehydes with Aryl Iodides.Chemistry (Weinheim an der Bergstrasse, Germany) · 2024Article
- Cross-Electrophile Coupling: Principles, Methods, and Applications in Synthesis.Chemical reviews · 2024Review
- Electrochemically Driven Nickel-Catalyzed Enantioselective Hydro-Arylation/Alkenylation of Enones.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Nickel-Catalyzed Electrochemical Cross-Electrophile C(spAngewandte Chemie (International ed. in English) · 2024Article
- Asymmetric paired oxidative and reductive catalysis enables enantioselective alkylarylation of olefins with C(spNature communications · 2024Article
- Photoelectrochemical Fe/Ni cocatalyzed C-C functionalization of alcohols.Nature communications · 2024Article
- Electro/Ni Dual-Catalyzed Decarboxylative C(spAngewandte Chemie (International ed. in English) · 2024Article
- Variation of Activation Volume as an Indicator of the Difference in Clusterization Phenomenon Induced by H-Bonding and F-Π Stacking Interactions in Enantiomers and a Racemate of Flurbiprofen.The journal of physical chemistry. B · 2024Article
- Enantioselective Csp3-Csp3 formation by nickel-catalyzed enantioconvergent cross-electrophile alkyl-alkyl coupling of unactivated alkyl halides.Science advances · 2023Article
- Ni-Electrocatalytic Enantioselective Doubly Decarboxylative C(spJournal of the American Chemical Society · 2023Article
- Nickel/biimidazole-catalyzed electrochemical enantioselective reductive cross-coupling of aryl aziridines with aryl iodides.Nature communications · 2023Article
- Nickel-Catalyzed Enantioselective Electrochemical Reductive Cross-Coupling of Aryl Aziridines with Alkenyl Bromides.Journal of the American Chemical Society · 2023Article
- Electroreductively Induced Radicals for Organic Synthesis.Molecules (Basel, Switzerland) · 2023Review
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Authors and funding
7 authors.
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Abstract
Electrochemical asymmetric catalysis has emerged as a sustainable and promising approach to the production of chiral compounds and the utilization of both the anode and cathode as working electrodes would provide a unique approach for organic synthesis. However, precise matching of the rate and electric potential of anodic oxidation and cathodic reduction make such idealized electrolysis difficult to achieve. Herein, asymmetric cross-coupling between α-chloroesters and aryl bromides is probed as a model reaction, wherein alkyl radicals are generated from the α-chloroesters through a sequential oxidative electron transfer process at the anode, while the nickel catalyst is reduced to a lower oxidation state at the cathode. Radical clock studies, cyclic voltammetry analysis, and electron paramagnetic resonance experiments support the synergistic involvement of anodic and cathodic redox events. This electrolytic method provides an alternative avenue for asymmetric catalysis that could find significant utility in organic synthesis.
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