Evidence map›Paper›PMID 36443296›Full record

ArticleNature communications2022

The fate of early perichondrial cells in developing bones.

Yuki Matsushita, Angel Ka Yan Chu, Chiaki Tsutsumi-Arai, Shion Orikasa, Mizuki Nagata, Sunny Y Wong, Joshua D Welch, Wanida Ono, Noriaki Ono

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
3.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Bridging skeletal stem cell diversity and human skeletal modeling.Journal of bone and mineral metabolism · 2026
    Review
  8. Review
  9. Stage-resolved geography of mouse skeletal stem cells.Journal of bone and mineral metabolism · 2026
    Review
  10. Article
  11. Article
  12. Fibrous-layer resident Angptl7Cell research · 2026
    Article
  13. Article
  14. Review
  15. Early determination of the dorsal-ventral axis in endochondral ossification in mice.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025
    Article
  16. Article
  17. The Periosteum in Health and Disease.Current osteoporosis reports · 2025
    Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Yuki MatsushitaUniversity of Texas Health Science Center at Houston School of Dentistry, Houston, TX, 77054, USA.
Angel Ka Yan ChuDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA.
Chiaki Tsutsumi-AraiUniversity of Texas Health Science Center at Houston School of Dentistry, Houston, TX, 77054, USA.
Shion OrikasaUniversity of Texas Health Science Center at Houston School of Dentistry, Houston, TX, 77054, USA.
Mizuki NagataUniversity of Texas Health Science Center at Houston School of Dentistry, Houston, TX, 77054, USA.
Sunny Y WongDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Joshua D WelchDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA.
Wanida OnoUniversity of Texas Health Science Center at Houston School of Dentistry, Houston, TX, 77054, USA.
Noriaki OnoUniversity of Texas Health Science Center at Houston School of Dentistry, Houston, TX, 77054, USA. noriaki.ono@uth.tmc.edu.ORCID 0000-0002-3771-8230
The University of Texas Health Science Center at Houston · USUniversity of Michigan · USNagasaki University · JPThe University of Texas Health Science Center · US

Funding

Quantitative definition of cell identity from single-cell multi-omic, spatial, and perturbation dataR01HG010883 · NHGRI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Joshua Welch · 2019 to 2026
$4.4M
The Hair Follicle Infundibulum: A Potential Mediator of Skin Barrier FunctionR01AR065409 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Sunny Y Wong · 2014 to 2026
$3.8M
Craniofacial skeletal cell lineage plasticity for reconstituting stem cells and their nichesR01DE030630 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ONO, NORIAKI, ONO, WANIDA · 2021 to 2025
$2.2M
Dynamics and Regulations of Bone Stem Cells in VivoR01DE026666 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ONO, NORIAKI · 2018 to 2022
$2.1M
Exploring hair follicle-associated functions in normal and ichthyotic skinR01AR080654 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Sunny Y Wong · 2022 to 2026
$2.0M
Dental Follicle: A Central Regulator of Tooth Root Formation and RegenerationR01DE029181 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ONO, WANIDA · 2021 to 2025
$1.9M
NHGRI NIH HHS R01 HG010883NIAMS NIH HHS R01 AR065409NIAMS NIH HHS R01 AR080654NIDCR NIH HHS R01 DE026666NIDCR NIH HHS R01 DE029181NIDCR NIH HHS R01 DE030630
6 · The paper itself

Abstract

In endochondral bone development, bone-forming osteoblasts and bone marrow stromal cells have dual origins in the fetal cartilage and its surrounding perichondrium. However, how early perichondrial cells distinctively contribute to developing bones remain unidentified. Here we show using in vivo cell-lineage analyses that Dlx5

Indexed as

CartilageHedgehog ProteinsAdultBone and BonesBone DevelopmentChondrocytesHumansHedgehog Proteins

Identifiers

PMID36443296
PMCPMC9705540
OpenAlexW4310179621

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.