ArticleNature communications2022
DNA methylation-based classification of sinonasal tumors.
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Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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53citing papers in PubMed
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Who cites it
53 citing papers in PubMed, 83 citations in OpenAlex.
- Predominance of In-Field Recurrence After Radiotherapy for Sinonasal Cancer: A Single-Center Retrospective Study.Head & neck · 2026Article
- Methylation profiling in CNS tumor diagnostics: a single-centre real-world experience from Central Europe.Virchows Archiv : an international journal of pathology · 2026Article
- Nano-RAPID: Integrated Diagnosis for Sarcoma Using a Nanopore Sequencer.Genes, chromosomes & cancer · 2026Article
- Sellar region neurocytomas exhibit a CIMP and neuroendocrine-like epigenetic signature distinct from other intra-axial neurocytomas.Acta neuropathologica · 2026Article
- Epigenetic alterations in head and neck cancer: a brief update.Virchows Archiv : an international journal of pathology · 2026Review
- Skeletal muscle reprogramming of metabolic, ribosomal and developmental pathways contributes to Roux-en-Y gastric bypass-induced adaptation in women.EBioMedicine · 2026Article
- Accurate Prediction of Central Conventional Chondrosarcoma Risk and Outcome Using Methylation Profiling: CHROME.Genes, chromosomes & cancer · 2026Article
- Integrating artificial intelligence into cancers of unknown primary diagnosis and treatment.iScience · 2026Review
- Single nucleus RNA profiling reveals potential therapeutic vulnerabilities in sinonasal carcinomas.NPJ precision oncology · 2026Article
- Comprehensive Genomic Profiling of Sinonasal Carcinomas: Identification of Common Mutations and Potential Targets for Therapy.Journal of neurological surgery. Part B, Skull base · 2026Article
- Spatially resolved ex vivo drug response profiling in SMARCB1-deficient sinonasal carcinoma.EMBO molecular medicine · 2026Article
- A Genomic and Epigenetic Comparative Study of Low-grade Biphenotypic Sinonasal Sarcoma with Metachronous and Synchronous High-grade Rhabdomyosarcomatous Transformation.Head and neck pathology · 2026Article
- CnQuant: high-resolution chromosomal copy number profiling for precision oncology in the clinics.Acta neuropathologica · 2026Article
- SMARCA4-deficient carcinoma of the head and neck region: report of 8 new sinonasal and non-sinonasal cases and literature review.Virchows Archiv : an international journal of pathology · 2026Review
- Artificial Intelligence Design for Race-Based Prostate Cancer Stage Classification With Multilayer Perceptron: Feature Selection Optimization Approach.JMIR formative research · 2026Article
- Comprehensive molecular analyses for diagnosis and treatment guidance in an adult neuroblastoma patient.The oncologist · 2026Article
- Genomic and Immune Correlates of EZH2 Expression and Activity in Olfactory Neuroblastoma.Head & neck · 2026Article
- Clinical, genetic and immunohistochemical characterization of sinonasal tumors with neuroectodermal differentiation.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Single-Nucleus Multi-Omics Reveals Hypoxia-Driven Angiogenic Programs and Their Epigenetic Control in Sinonasal Squamous Cell Carcinoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- From Classical to Emerging Biomarkers of Brain and Central Nervous System Tumors. An Evidence-Based Review with a Focus on Gliomas.Cellular and molecular neurobiology · 2026Review
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Authors and funding
66 authors at 20 institutions in 7 countries.
Philipp JurmeisterInstitute of Pathology, Ludwig Maximilians University Hospital Munich, Munich, Germany. philipp.jurmeister@med.uni-muenchen.de.
Stefanie GlößCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Neuropathology, Charitéplatz 1, Berlin, Germany.
Renée RollerInstitute of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Maximilian LeitheiserInstitute of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Simone SchmidGerman Cancer Consortium (DKTK), Partner Site Berlin, and German Cancer Research Center (DKFZ), Heidelberg, Germany.
Liliana H MochmannInstitute of Pathology, Ludwig Maximilians University Hospital Munich, Munich, Germany.
Emma Payá CapillaInstitute of Pathology, Ludwig Maximilians University Hospital Munich, Munich, Germany.
Rebecca FritzInstitute of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Carsten DittmayerCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Neuropathology, Charitéplatz 1, Berlin, Germany.
Corinna FriedrichInstitute of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Anne ThiemeGerman Cancer Consortium (DKTK), Partner Site Berlin, and German Cancer Research Center (DKFZ), Heidelberg, Germany.
Philipp KeylInstitute of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Armin JaroschInstitute of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Simon SchallenbergInstitute of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Hendrik BläkerInstitute of Pathology, University Hospital Leipzig, Leipzig, Germany.
Inga HoffmannInstitute of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Claudia VollbrechtInstitute of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Annika LehmannInstitute of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Michael HummelInstitute of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Daniel HeimInstitute of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Mohamed HajiProteomics Platform, Berlin Institute of Health (BIH) and Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125, Berlin, Germany.
Patrick HarterGerman Cancer Consortium (DKTK), Partner Site Munich, and German Cancer Research Center (DKFZ), Heidelberg, Germany.
Benjamin EnglertInstitute of Neuropathology, Ludwig Maximilians University Hospital Munich, Munich, Germany.ORCID 0000-0002-1769-5393
Stephan FrankDepartment of Neuropathology, Institute of Pathology, Basel University Hospital, Basel, Switzerland.ORCID 0000-0001-6165-0187
Jürgen HenchDepartment of Neuropathology, Institute of Pathology, Basel University Hospital, Basel, Switzerland.
Werner PaulusInstitute of Neuropathology, University Hospital Münster, Münster, Germany.
Martin HasselblattInstitute of Neuropathology, University Hospital Münster, Münster, Germany.
Wolfgang HartmannDivision of Translational Pathology, Gerhard-Domagk-Institute of Pathology, University Hospital Münster, Münster, Germany.ORCID 0000-0002-7609-5021
Hildegard DohmenInstitute of Neuropathology, University of Giessen, Giessen, Germany.
Ursula KeberInstitute of Neuropathology, Philipps-University, Marburg, Germany.ORCID 0000-0002-0539-7065
Paul JankInstitute of Pathology, Philipps-University Marburg and University Hospital Marburg, Marburg, Germany.ORCID 0000-0001-7076-0476
Carsten DenkertInstitute of Pathology, Philipps-University Marburg and University Hospital Marburg, Marburg, Germany.ORCID 0000-0002-2249-0982
Christine StadelmannInstitute for Neuropathology, University Medical Centre Göttingen, Göttingen, Germany.ORCID 0000-0003-1766-5458
Felix BremmerInstitute of Pathology, University Medical Center, Göttingen, Germany.
Annika RichterInstitute of Pathology, University Medical Center, Göttingen, Germany.
Annika WefersDepartment of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.
Julika Ribbat-IdelInstitute of Pathology, University of Luebeck and University Hospital Schleswig-Holstein, Campus Luebeck, Luebeck, Germany.
Sven PernerInstitute of Pathology, University of Luebeck and University Hospital Schleswig-Holstein, Campus Luebeck, Luebeck, Germany.
Christian IdelDepartment of Otorhinolaryngology, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.
Lorenzo ChiariottiDipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, Via S. Pansini 5, 80131, Naples, Italy.
Rosa Della MonicaCEINGE Biotecnologie Avanzate, 80145, Naples, Italy.
Alfredo MarinelliDepartment of Medicina Clinica e Chirurgia, University Federico II, Naples, Italy.
Ulrich SchüllerInstitute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0002-8731-1121
Michael BockmayrInstitute of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0002-9249-4292
Jacklyn LiuUCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6BT, UK.
Valerie J LundUCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6BT, UK.
Martin ForsterUCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6BT, UK.
Matt LechnerUCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6BT, UK.ORCID 0000-0002-7123-0773
Sara L Lorenzo-GuerraDepartment of Head and Neck Oncology, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain.
Mario HermsenDepartment of Head and Neck Oncology, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain.ORCID 0000-0002-5959-6289
Pascal D JohannSwabian Childrens' Cancer Center, University Childrens' Hospital Augsburg and EU-RHAB Registry, Augsburg, Germany.
Abbas AgaimyInstitute of Pathology, Friedrich-Alexander-University Erlangen-Nürnberg, University Hospital, Erlangen, Germany.ORCID 0000-0002-0445-8161
Philipp SeegererMachine-Learning Group, Department of Software Engineering and Theoretical Computer Science, Technical University of Berlin, Berlin, Germany.ORCID 0000-0002-4707-7991
Arend KochCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Neuropathology, Charitéplatz 1, Berlin, Germany.
Frank HeppnerGerman Cancer Consortium (DKTK), Partner Site Berlin, and German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0001-9816-8917
Stefan M PfisterHopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
David T W JonesHopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
Martin SillHopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
Andreas von DeimlingDepartment of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.ORCID 0000-0002-5863-540X
Matija SnuderlDivision of Neuropathology, NYU Langone Health, New York, USA.
Klaus-Robert MüllerMachine-Learning Group, Department of Software Engineering and Theoretical Computer Science, Technical University of Berlin, Berlin, Germany.
Erna ForgóStanford University School of Medicine, Stanford, CA, USA.
Brooke E HowittStanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-0309-6680
Philipp MertinsProteomics Platform, Berlin Institute of Health (BIH) and Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125, Berlin, Germany.ORCID 0000-0002-2245-528X
Frederick Klauschen *Institute of Pathology, Ludwig Maximilians University Hospital Munich, Munich, Germany.
David Capper *German Cancer Consortium (DKTK), Partner Site Berlin, and German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0003-1945-497X
German Cancer Research Center · DEHumboldt-Universität zu Berlin · DEUniversity College London · GBLudwig-Maximilians-Universität München · DEPhilipps University of Marburg · DEUniversität Hamburg · DEUniversity Hospital Münster · DEUniversity Hospital Schleswig-Holstein · DECeinge Biotecnologie Avanzate (Italy) · ITInstituto de Investigación Sanitaria del Principado de Asturias · ESMax Delbrück Center · DEStanford University · USUniversitätsmedizin Göttingen · DEUniversity Hospital of Basel · CHFederico II University Hospital · ITFriedrich-Alexander-Universität Erlangen-Nürnberg · DEGoethe University Frankfurt · DEHopp Children's Cancer Center Heidelberg · DEJustus-Liebig-Universität Gießen · DEKorea University · KR
Funding
No grant is acknowledged in the PubMed record.
Abstract
The diagnosis of sinonasal tumors is challenging due to a heterogeneous spectrum of various differential diagnoses as well as poorly defined, disputed entities such as sinonasal undifferentiated carcinomas (SNUCs). In this study, we apply a machine learning algorithm based on DNA methylation patterns to classify sinonasal tumors with clinical-grade reliability. We further show that sinonasal tumors with SNUC morphology are not as undifferentiated as their current terminology suggests but rather reassigned to four distinct molecular classes defined by epigenetic, mutational and proteomic profiles. This includes two classes with neuroendocrine differentiation, characterized by IDH2 or SMARCA4/ARID1A mutations with an overall favorable clinical course, one class composed of highly aggressive SMARCB1-deficient carcinomas and another class with tumors that represent potentially previously misclassified adenoid cystic carcinomas. Our findings can aid in improving the diagnostic classification of sinonasal tumors and could help to change the current perception of SNUCs.
Indexed as
CarcinomaDNA MethylationDNA HelicasesHumansMaxillary Sinus NeoplasmsNuclear ProteinsProteomicsReproducibility of ResultsTranscription FactorsDNA HelicasesNuclear ProteinsSMARCA4 protein, humanTranscription Factors
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