Evidence map›Paper›PMID 36442960›Full record

ReviewPET clinics2023

Brain PET Imaging: Frontotemporal Dementia.

Joshua Ward, Maria Ly, Cyrus A Raji

Open access · greenAbstract readReview
In one paragraph

Review in PET clinics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 29 citations in OpenAlex.

  1. Synaptic density imaging in behavioral variant frontotemporal dementia: A comparison ofAlzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
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  15. Relationship between neuroimaging and cognition in frontotemporal dementia: An FDG-PET and structural MRI study.Journal of neuroimaging : official journal of the American Society of Neuroimaging
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Joshua WardDivision of Neuroradiology, Mallinckrodt Institute of Radiology, Washington University in Saint. Louis, Saint Louis, MO 63130, USA.
Maria LyDivision of Neuroradiology, Mallinckrodt Institute of Radiology, Washington University in Saint. Louis, Saint Louis, MO 63130, USA.
Cyrus A RajiDivision of Neuroradiology, Mallinckrodt Institute of Radiology, Washington University in Saint. Louis, Saint Louis, MO 63130, USA; Department of Neurology, Washington University in St. Louis, 4525 Scott Avenue, St. Louis, MO 63110, USA. Electronic address: craji@wustl.edu.
Mallinckrodt (United States) · USWashington University in St. Louis · US

Funding

Neuroinflammation and Alzheimer's Disease Imaging Biomarkers in Midlife ObesityRF1AG072637 · NIA · WASHINGTON UNIVERSITY · PI RAJI, CYRUS A · 2021 to 2021
$2.3M
Neuroinflammation and Alzheimer's Disease Imaging Biomarkers in Midlife ObesityR01AG072637 · NIA · WASHINGTON UNIVERSITY · PI RAJI, CYRUS A · 2024 to 2025
$1.4M
NIA NIH HHS R01 AG072637NIA NIH HHS RF1 AG072637
6 · The paper itself

Abstract

Brain PET adds value in diagnosing neurodegenerative disorders, especially frontotemporal dementia (FTD) due to its syndromic presentation that overlaps with a variety of other neurodegenerative and psychiatric disorders. 18F-FDG-PET has improved sensitivity and specificity compared with structural MR imaging, with optimal diagnostic results achieved when both techniques are utilized. PET demonstrates superior sensitivity compared with SPECT for FTD diagnosis that is primarily a supplement to other imaging and clinical evaluations. Tau-PET and amyloid-PET primary use in FTD diagnosis is differentiation from Alzheimer disease, although these methods are limited mainly to research settings.

Indexed as

Alzheimer DiseaseFrontotemporal DementiaBrainHumansPositron-Emission TomographyTomography, Emission-Computed, Single-Photon(18)F-FDG-PETAlzheimer disease (AD)Amyloid-PETFrontotemporal dementia (FTD)MRINeurodegenerative disorders fused-in-sarcoma protein (FUS)SPECTTau-PET

Identifiers

PMID36442960
PMCPMC9884902
OpenAlexW4310019068

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.