Evidence map›Paper›PMID 36442719›Full record

ReviewThe Journal of nutritional biochemistry2023

Interplay of broccoli/broccoli sprout bioactives with gut microbiota in reducing inflammation in inflammatory bowel diseases.

Johanna Holman, Molly Hurd, Peter L Moses, Gary M Mawe, Tao Zhang, Suzanne L Ishaq, Yanyan Li

Open access · greenAbstract readReview
In one paragraph

Review in The Journal of nutritional biochemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 34 citations in OpenAlex.

  1. Trial
  2. Foods (Basel, Switzerland) · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. The Anti-AGEing and RAGEing Potential of Isothiocyanates.Molecules (Basel, Switzerland) · 2024
    Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. A review for non-antibiotic treatment ofFrontiers in microbiology · 2024
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Johanna HolmanSchool of Food and Agriculture, University of Maine, Orono, Maine, USA.
Molly HurdLarner College of Medicine, University of Vermont, Burlington, Vermont, USA.
Peter L MosesLarner College of Medicine, University of Vermont, Burlington, Vermont, USA; Finch Therapeutics, Somerville, Massachusetts, USA.
Gary M MaweLarner College of Medicine, University of Vermont, Burlington, Vermont, USA.
Tao ZhangSchool of Pharmacy and Pharmaceutical Sciences, SUNY Binghamton University, Johnson City, New York, USA.
Suzanne L IshaqSchool of Food and Agriculture, University of Maine, Orono, Maine, USA. Electronic address: sue.ishaq@maine.edu.
Yanyan LiSchool of Food and Agriculture, University of Maine, Orono, Maine, USA. Electronic address: yanyan.li@maine.edu.
University of Maine · USUniversity of Vermont · USBinghamton University · US

Funding

Harnessing gut microbiota to reduce inflammation using broccoli-sprout dietsR15DK133826 · NIDDK · UNIVERSITY OF MAINE ORONO · PI PELLEGRINI, SUZANNE ISHAQ · 2022 to 2022
$436k
Use of tryptophan-synthesizing bacteria to enhance intestinal motilityR21AT011203 · NCCIH · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI LAVOIE, BRIGITTE · 2021 to 2022
$421k
NCCIH NIH HHS R21 AT011203NIDDK NIH HHS R15 DK133826
6 · The paper itself

Abstract

Inflammatory Bowel Diseases (IBD) are chronic, reoccurring, and debilitating conditions characterized by inflammation in the gastrointestinal tract, some of which can lead to more systemic complications and can include autoimmune dysfunction, a change in the taxonomic and functional structure of microbial communities in the gut, and complicated burdens in a person's daily life. Like many diseases based in chronic inflammation, research on IBD has pointed towards a multifactorial origin involving factors of the person's lifestyle, immune system, associated microbial communities, and environmental conditions. Treatment currently exists only as palliative care, and seeks to disrupt the feedback loop of symptoms by reducing inflammation and allowing as much of a return to homeostasis as possible. Various anti-inflammatory options have been explored, and this review focuses on the use of diet as an alternative means of improving gut health. Specifically, we highlight the connection between the role of sulforaphane from cruciferous vegetables in regulating inflammation and in modifying microbial communities, and to break down the role they play in IBD.

Indexed as

BrassicaGastrointestinal MicrobiomeInflammatory Bowel DiseasesDietHumansInflammationBroccoliBroccoli sproutsCrohn's DiseaseDietary bioactivesGlucoraphaninGut microbiotaInflammatory bowel diseaseSulforaphaneUlcerative colitis

Identifiers

PMID36442719
PMCPMC9974906
OpenAlexW4310065822

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.