ReviewNeuropharmacology2023
The role of dlPFC laterality in the expression and regulation of anxiety.
Review in Neuropharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Combined Use of Electroencephalography and Transcranial Electrical Stimulation: A Systematic Review.Sensors (Basel, Switzerland) · 2025Pooled it
- The convergent neuroscience of Christian prayer and attachment relationships in the context of mental health: a systematic review.Frontiers in psychology · 2025Pooled it
- Effects of Oral Contraceptive Pills on Brain Networks: A Conceptual Replication and Extension.Human brain mapping · 2025Trial
- Impact of Intermittent Theta Burst Stimulation on Pain Relief and Brain Connectivity in Chronic Low Back Pain.European journal of pain (London, England) · 2025Trial
- Intermittent theta-burst stimulation to the right dorsolateral prefrontal cortex may increase potentiated startle in healthy individuals.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Trial
- tDCS reduces depression and state anxiety symptoms in older adults from the augmenting cognitive training in older adults study (ACT).Brain stimulationTrial
- Sex-differences in resting state dorsolateral prefrontal cortex: comparing motion correction methods in resting state functional near-infrared spectroscopy (fNIRS).Brain structure & function · 2026Article
- Parent-Child Neural Dynamics during a Stressful Task: Probing Associations with Temperament and Anxiety.Clinical psychological science : a journal of the Association for Psychological Science · 2026Article
- Examining dynamic changes in prefrontal connectivity and internalizing symptoms during the first and third trimesters of pregnancy.Journal of neuroendocrinology · 2026Article
- Effects of MRI-Navigated Intermittent Theta Burst Stimulation on Task Performance, Subjective Workload, and EEG Responses During Prolonged Simulated Flight: A Randomized Crossover Study.Bioengineering (Basel, Switzerland) · 2026Article
- Neural Mechanism of the Emotional Process During the Bonny Method of Guided Imagery and Music: A Functional Near-infrared Spectroscopy Study.Brain topography · 2026Article
- Sustained dorsolateral prefrontal cortex response to prosocial reward predicts lower real-world negative emotional inertia.Cognitive, affective & behavioral neuroscience · 2026Article
- Cyber-victimized and cognitively fogged? Cyberbullying victimization and executive function.BMC public health · 2026Article
- Common and distinct neurofunctional signatures of dynamic naturalistic emotion regulation strategies.Nature communications · 2026Article
- Cortical-limbic circuit dynamics of approach-avoidance conflict in humans.Nature communications · 2026Article
- The dorsolateral prefrontal cortex as a potential target for electrical stimulation in the treatment of vestibular-based nausea.The Journal of physiology · 2026Review
- Longitudinal changes in T1w/T2w estimates of cortical myelin with age and pubertal timing.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Reward-related language processing of maternal speech in infants at different likelihood of ASD.Social cognitive and affective neuroscience · 2026Article
- Parental leadership in motion: neural and behavioral mechanisms of synchrony during parent-child interaction.Social cognitive and affective neuroscience · 2026Article
- The neural basis of explicit and implicit emotion regulation: a coordinate-based meta-analysis.Oxford open neuroscience · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Anxiety disorders are the most common mental health disorder. Therefore, elucidating brain mechanisms implicated in anxiety disorders is important avenue for developing novel treatments and improving care. The dorsolateral prefrontal cortex (dlPFC) is thought to be critically involved in working memory processes (i.e. maintenance, manipulation, suppression, etc.). In addition, there is evidence that this region is involved in anxiety regulation. However, it is unclear how working memory related dlPFC processes contribute to anxiety regulation. Furthermore, we know that laterality plays an important role in working memory related dlPFC processing, however there is no current model of dlPFC mediated anxiety regulation that accounts for potential laterality effects. To address this gap, we propose a potential framework where the dlPFC contributes to emotion regulation via working memory processing. According to this framework, working memory is a fundamental process executed by the dlPFC. However, the domain of content differs across the left and right dlPFC, with the left dlPFC sensitive to primarily verbal content, and the right dlPFC sensitive to primarily non-verbal (affective content). Critically, working memory processes allow for both the retention and suppression of affective information in working memory and the overall net effect of processing on mood will depend on the balance of retention and suppression, the valence of the information being processed (positive vs. negative), and the domain of the information (verbal vs. non-verbal). If accurate, the proposed framework predicts that effects of neuromodulation targeting the dlPFC may be dependent upon the context during which the stimulation is presented. This article is part of the Special Issue on 'Fear, Anxiety and PTSD'.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.