ArticleNucleic acids research2023
Origins of transfer establish networks of functional dependencies for plasmid transfer by conjugation.
Article in Nucleic acids research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Mobile genetic elements drive a plasmid fusion and deletion lifecycle shaping evolution and antimicrobial resistance.Nature communications · 2026Article
- The shared evolutionary capacities of plasmids and extrachromosomal DNA.Nature reviews. Genetics · 2026Review
- Perturbations shift the composition of bacterial DNA carried by virus-like particles in the murine gut microbiome.bioRxiv : the preprint server for biology · 2026Article
- Comparative genomics and methylome profiling ofMicrobial genomics · 2026Article
- Phenotypic and genotypic characterization of antimicrobial resistance in coagulase-negative staphylococci from bone lesions in broiler chickens.BMC veterinary research · 2026Article
- Bovine-DerivedMicroorganisms · 2026Article
- Genomic insight into the antibiotic-resistant determinants ofFrontiers in microbiology · 2026Article
- Transfer potential of F-like plasmids inISME communications · 2026Article
- An integrated genomic and phenotypic insight into safety performance and probiotic potential of a novel strainFrontiers in microbiology · 2026Article
- Clinical and Environmental Plasmids: Antibiotic Resistance, Virulence, Mobility, and ESKAPEE Pathogens.Antibiotics (Basel, Switzerland) · 2025Article
- ProFiT-SPEci-FISH: a novel approach for linking plasmids to hosts in complex microbial communities at the single-cell level.Microbiome · 2025Article
- Localization of the origin of transfer for Salmonella genomic island 4 from Salmonella enterica serovar I 4,[5],12:i:.DNA research : an international journal for rapid publication of reports on genes and genomes · 2025Article
- A global soil plasmidome resource unveils functional and ecological roles of plasmids in soil microbiomes.Nature communications · 2025Article
- Persistent multispecies dissemination ofJournal of clinical microbiology · 2025Article
- Evolution of the Plant-Associated Pantoea was Accompanied by Plasmid Domestication Events.Molecular biology and evolution · 2025Article
- Plasmid Genomic Dynamics and One Health: Drivers of Antibiotic Resistance and Pathogenicity.Pathogens (Basel, Switzerland) · 2025Review
- Tracing the evolutionary dynamics of carbapenem-resistant Escherichia coli in recurrent and multi-site infections.Gut pathogens · 2025Article
- The extended mobility of plasmids.Nucleic acids research · 2025Review
- Universal rules govern plasmid copy number.Nature communications · 2025Article
- Scaling laws of bacterial and archaeal plasmids.Nature communications · 2025Article
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Plasmids can be transferred between cells by conjugation, thereby driving bacterial evolution by horizontal gene transfer. Yet, we ignore the molecular mechanisms of transfer for many plasmids because they lack all protein-coding genes required for conjugation. We solved this conundrum by identifying hundreds of plasmids and chromosomes with conjugative origins of transfer in Escherichia coli and Staphylococcus aureus. These plasmids (pOriT) hijack the relaxases of conjugative or mobilizable elements, but not both. The functional dependencies between pOriT and other plasmids explain their co-occurrence: pOriT are abundant in cells with many plasmids, whereas conjugative plasmids are the most common in the others. We systematically characterized plasmid mobility in relation to conjugation and alternative mechanisms of transfer and can now propose a putative mechanism of transfer for ∼90% of them. In most cases, plasmid mobility seems to involve conjugation. Interestingly, the mechanisms of mobility are important determinants of plasmid-encoded accessory traits, since pOriTs have the highest densities of antimicrobial resistance genes, whereas plasmids lacking putative mechanisms of transfer have the lowest. We illuminate the evolutionary relationships between plasmids and suggest that many pOriT may have arisen by gene deletions in other types of plasmids. These results suggest that most plasmids can be transferred by conjugation.
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