Evidence map›Paper›PMID 36442467›Full record

Trial reportNeonatology2023

Total Fluid Administration and Weight Loss during the First 2 Weeks in Infants Randomized to Early Enteral Feeding after Extremely Preterm Birth.

Leandra Durham, Emily Gunawan, Kelly Nguyen, Audrey Reeves, Vivek Shukla, Ariel A Salas

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neonatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02915549 (Early Progressive Feeding in Human-Milk Fed Extremely Preterm Infants), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02915549 nacompletednot on this map

Early Progressive Feeding in Human-Milk Fed Extremely Preterm Infants: A Randomized Trial

TypeinterventionalSponsorUniversity of Alabama at BirminghamRan2016 to 2022Enrolled60ConditionsPremature, Infant, Light-for-datesArmsProgressive Feeding without MEF, Progressive Feeding with MEF
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Leandra DurhamDepartment of Pediatrics, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Emily GunawanDepartment of Pediatrics, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Kelly NguyenDepartment of Pediatrics, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Audrey ReevesDepartment of Pediatrics, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Vivek ShuklaDepartment of Pediatrics, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Ariel A SalasDepartment of Pediatrics, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
University of Alabama at Birmingham · US

Funding

Early life protein-enriched human milk diets to increase lean body mass accretion and diversity of the gut microbiome in extremely preterm infants: a randomized trialK23HD102554 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SALAS, ARIEL · 2020 to 2024
$774k
NICHD NIH HHS K23 HD102554
6 · The paper itself

Abstract

backgroundRandomized trials have not reported the effects of the early progression of feeding volumes on fluid balance and neurodevelopment among infants born extremely preterm (≤28 weeks).

methodFluid, electrolyte, and neurodevelopment data of 60 extremely preterm infants randomly assigned to receive either 1 (early feeding group) or 4 days (late feeding group) of trophic feeding volumes at 20-24 mL/kg/day were analyzed.

resultsInfants randomized to the early feeding group received less parenteral fluids, generated lower urine volumes, and had less excessive weight loss during the first 14 days after birth. The 7-point difference in cognitive scores and the 0.5 difference in weight-for-age z-scores favoring the early feeding group did not reach statistical significance.

conclusionsIn extremely preterm infants, early enteral feeding is associated with less total fluid administration and with less excessive weight loss during the first 2 weeks after birth. These short-term effects could have long-lasting benefits.

Indexed as

Enterocolitis, NecrotizingPremature BirthEnteral NutritionFemaleHumansInfantInfant, Extremely PrematureInfant, NewbornInfant, Very Low Birth WeightWeight LossAnthropometricsClinical trialElectrolyte disturbancesNeurodevelopmentNutritionPostnatal growthPremature infants

Identifiers

PMID36442467
PMCPMC10038856
OpenAlexW4310182881

What OpenQuestion holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.