Evidence map›Paper›PMID 36442366›Full record

ArticleParkinsonism & related disorders2023

Subjective cognitive complaints are important in PD-MCI criteria: Associations with CSF markers and cognitive decline.

Jacob D Jones, Rhiannon Rivas, Kenya Luna, Cameron A Ryczek, Kelsey R Thomas

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parkinsonism & related disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jacob D JonesDepartment of Psychology, Center on Aging, California State University San Bernardino, San Bernardino, CA, USA. Electronic address: Jacob.jones@csusb.edu.
Rhiannon RivasDepartment of Psychology, Center on Aging, California State University San Bernardino, San Bernardino, CA, USA.
Kenya LunaDepartment of Psychology, Center on Aging, California State University San Bernardino, San Bernardino, CA, USA.
Cameron A RyczekDepartment of Psychology, Center on Aging, California State University San Bernardino, San Bernardino, CA, USA.
Kelsey R ThomasVeteran Affairs San Diego Healthcare System, San Diego, CA, USA; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
California State University, San Bernardino · USUniversity of California San Diego · US

Funding

Microbiome Composition and Function Contributes to Cognitive Impairment and Neuroinflammation in Parkinson’s DiseaseSC3NS124906 · NINDS · CALIFORNIA STATE UNIV SAN BERNARDINO · PI JONES, JACOB D · 2021 to 2024
$438k
Identifying best methods for the detection of subtle cognitive declineR03AG070435 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI THOMAS, KELSEY R · 2021 to 2022
$316k
CSRD VA IK2 CX001865NIA NIH HHS R03 AG070435NINDS NIH HHS SC3 NS124906
6 · The paper itself

Abstract

introductionAccording to the Movement Disorder Society (MDS), subjective cognitive complaints (SCC) are a diagnostic criterion for PD-mild cognitive impairment (PD-MCI); however, studies often do not incorporate SCC when classifying PD-MCI. This inconsistent use may reflect mixed findings regarding the association between SCC and objective measures of cognitive impairment. Our study aimed to describe the extent that inclusion/exclusion of SCC affects the occurrence of PD-MCI, and if the inclusion of SCC is associated with faster cognitive decline and cerebrospinal fluid markers (CSF) of alpha-synuclein, amyloid beta, total tau, and phophorylated-tau.

methodsIndividuals with PD (N = 358) from the PPMI cohort whom completed measures of neuropsychological performance, subjective cognitive complaints, motor severity, and CSF markers were included. Participants were classified as cognitively normal (CN), PD-MCI with subjective cognitive complaints (PD-MCI + SCC) and PD-MCI without subjective cognitive complaints (PD-MCI -SCC).

resultsPD-MCI rates were consistently higher (16.5-19.1%) across the 5 years when SCC was not included in the diagnostic criteria as opposed to when SCC was included (4.4-11.0%). PD-MCI + SCC experienced greater cognitive decline and had significantly higher levels of tau/ab and p-tau/ab relative to both the CN and PD-MCI - SCC groups.

conclusionsInconsistent implementation of an SCC requirement in PD-MCI classifications may have important implications in terms of the occurrence of PD-MCI and its prognostic value. Classifying PD-MCI only using neuropsychological cut-off criterion, without regard to SCC, may lead to higher rates of PD-MCI. Inclusions of SCC in PD-MCI criteria in newly diagnosed PD participants may strengthen the ability to detect individuals at risk for future cognitive decline, though it is possible that this decline is related to Alzheimer's disease changes rather than worse PD pathology.

Indexed as

Alzheimer DiseaseCognitive DysfunctionAmyloid beta-PeptidesBiomarkersCognitionHumansNeuropsychological Teststau ProteinsAmyloid beta-PeptidesBiomarkerstau ProteinsBiomarkersCognitive complaintsMild cognitive impairmentParkinson's disease

Identifiers

PMID36442366
PMCPMC10775883
OpenAlexW4309631165

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.