Evidence map›Paper›PMID 36442349›Full record

ReviewCurrent opinion in microbiology2023

Manipulation of host cell plasma membranes by intracellular bacterial pathogens.

Nora Kostow, Matthew D Welch

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Nora KostowDepartment of Molecular & Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Matthew D WelchDepartment of Molecular & Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: welch@berkeley.edu.
University of California, Berkeley · US

Funding

Rickettsia mobilization of the cytoskeleton during invasion, motility, and spreadR01AI109044 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI WELCH, MATTHEW D · 2014 to 2025
$5.6M
Microbial mobilization of the actin cytoskeletonR35GM127108 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Matthew D Welch · 2018 to 2026
$4.0M
NIAID NIH HHS R01 AI109044NIGMS NIH HHS R35 GM127108
6 · The paper itself

Abstract

Manipulation of the host cell plasma membrane is critical during infection by intracellular bacterial pathogens, particularly during bacterial entry into and exit from host cells. To manipulate host cells, bacteria deploy secreted proteins that modulate or modify host cell components. Here, we review recent advances that suggest common themes by which bacteria manipulate the host cell plasma membrane. One theme is that bacteria use diverse strategies to target or influence host cell plasma membrane composition and shape. A second theme is that bacteria take advantage of host cell plasma membrane-associated pathways such as signal transduction, endocytosis, and exocytosis. Future investigation into how bacterial and host factors contribute to plasma membrane manipulation by bacterial pathogens will reveal new insights into pathogenesis and fundamental principles of plasma membrane biology.

Indexed as

BacteriaEndocytosisCell MembraneHost-Pathogen InteractionsSignal Transduction

Identifiers

PMID36442349
PMCPMC10074913
OpenAlexW4310012562

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.