Evidence map›Paper›PMID 36442281›Full record

SynthesisJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association2023

Characteristics of subarachnoid hemorrhage associated with COVID-19 infection: A systematic review and descriptive analysis.

Mervyn Jun Rui Lim, Jonathan Yeo, Khi Yung Fong, Sean Wai-Onn Eng, Shuning Fu, Benjamin Yong-Qiang Tan, Leonard Leong Litt Yeo, Vincent Diong Weng Nga, Tseng Tsai Yeo

Open access · greenAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Mervyn Jun Rui LimDivision of Neurosurgery, University Surgical Centre, National University Hospital, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address: mervynlim@u.nus.edu.
Jonathan YeoYong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address: jonathan.yeo@u.nus.edu.
Khi Yung FongYong Loo Lin School of Medicine, National University of Singapore, Singapore.
Sean Wai-Onn EngYong Loo Lin School of Medicine, National University of Singapore, Singapore.
Shuning FuYong Loo Lin School of Medicine, National University of Singapore, Singapore.
Benjamin Yong-Qiang TanYong Loo Lin School of Medicine, National University of Singapore, Singapore; Division of Neurology, Department of Medicine, National University Hospital, Singapore.
Leonard Leong Litt YeoYong Loo Lin School of Medicine, National University of Singapore, Singapore; Division of Neurology, Department of Medicine, National University Hospital, Singapore.
Vincent Diong Weng NgaDivision of Neurosurgery, University Surgical Centre, National University Hospital, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Tseng Tsai YeoDivision of Neurosurgery, University Surgical Centre, National University Hospital, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
National University of Singapore · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveSubarachnoid hemorrhage (SAH) has been reported as a neurological manifestation in 0.1% of COVID-19 patients. This systematic review investigated the outcomes and predictive factors of SAH in patients with COVID-19. MATERIALS AND

methodsAn electronic literature search was conducted on PubMed, Embase, and Scopus from inception to 10

results17 case reports, 11 case series, and 2 retrospective cohort studies, with a total of 345 cases of SAH in COVID-19 patients, were included for analysis. Most published cases were reported in the US. Mean age was 55±18.4 years, and 162 patients (48.5%) were female. 242 patients (73.8%) had severe-to-critical COVID-19, 56.7% had aneurysmal SAH, 71.4% were on anticoagulation, and 10.8% underwent surgical treatment. 136 out of 333 patients (40.8%) died. Among patients with severe-to-critical COVID-19, 11 out of 18 (61.1%) died, and 8 out of 8 (100.0%) were non-aneurysmal SAH.

conclusionsSAH is a rare but morbid occurrence in COVID-19. The mortality rate of COVID-SAH patients was 40.8%, with a higher prevalence of severe-to-critical COVID-19 (100% versus 53.8%) and non-aneurysmal SAH (85.7% versus 44.6%) among COVID-SAH deaths. Given the changing landscape of COVID-19 variants, further studies investigating the association between COVID-19 and SAH may be warranted to identify the long-term effects of COVID-19.

Indexed as

COVID-19Subarachnoid HemorrhageAdultAgedFemaleHumansMaleMiddle AgedRetrospective StudiesSARS-CoV-2Treatment OutcomeCOVID-19NeurosurgerySubarachnoid hemorrhageSystematic review

Identifiers

PMID36442281
PMCPMC9678815
OpenAlexW4309726667

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.