Evidence map›Paper›PMID 36442202›Full record

Trial reportJournal of Alzheimer's disease : JAD2023

Impact of Computerized Cognitive Training on Default Mode Network Connectivity in Subjects at Risk for Alzheimer's Disease: A 78-week Randomized Controlled Trial.

Jeffrey R Petrella, Andrew M Michael, Min Qian, Adaora Nwosu, Joel Sneed, Terry E Goldberg, Davangere P Devanand, P Murali Doraiswamy

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of Alzheimer's disease : JAD, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Jeffrey R PetrellaDepartment of Radiology, Duke University School of Medicine, Durham, NC, USA.
Andrew M MichaelDuke Institute for Brain Sciences and the Duke Center for the Study of Aging and Human Development, Durham, NC, USA.
Min QianDepartment of Biostatistics, Mailman School of Public Health, Columbia University Medical Center, New York, NY, USA.
Adaora NwosuNeurocognitive Disorders Program, Department of Psychiatry, Duke University School of Medicine, Durham, NC, USA.
Joel SneedDepartment of Psychology, Queens College, City University of New York, Flushing, NY, USA.
Terry E GoldbergDepartment of Psychiatry, Columbia University Medical Center, and the New York Psychiatry Institute, New York, NY, USA.
Davangere P DevanandDepartment of Psychiatry, Columbia University Medical Center, and the New York Psychiatry Institute, New York, NY, USA.
P Murali DoraiswamyDuke Institute for Brain Sciences and the Duke Center for the Study of Aging and Human Development, Durham, NC, USA.
Duke University · USColumbia University Irving Medical Center · USQueens College, CUNY · US

Funding

COGNITIVE TRAINING AND NEUROPLASTICY IN MILD COGNITIVE IMPAIRMENTR01AG052440 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DAVANGERE P DEVANAND · 2017 to 2026
$9.3M
NIA NIH HHS R01 AG052440
6 · The paper itself

Abstract

backgroundMild cognitive impairment (MCI) represents a high risk group for Alzheimer's disease (AD). Computerized Cognitive Games Training (CCT) is an investigational strategy to improve targeted functions in MCI through the modulation of cognitive networks.

objectiveThe goal of this study was to examine the effect of CCT versus a non-targeted active brain exercise on functional cognitive networks.

methods107 patients with MCI were randomized to CCT or web-based crossword puzzles. Resting-state functional MRI (fMRI) was obtained at baseline and 18 months to evaluate differences in fMRI measured within- and between-network functional connectivity (FC) of the default mode network (DMN) and other large-scale brain networks: the executive control, salience, and sensorimotor networks.

resultsThere were no differences between crosswords and games in the primary outcome, within-network DMN FC across all subjects. However, secondary analyses suggest differential effects on between-network connectivity involving the DMN and SLN, and within-network connectivity of the DMN in subjects with late MCI. Paradoxically, in both cases, there was a decrease in FC for games and an increase for the crosswords control (p < 0.05), accompanied by lesser cognitive decline in the crosswords group.

conclusionResults do not support a differential impact on within-network DMN FC between games and crossword puzzle interventions. However, crossword puzzles might result in cognitively beneficial remodeling between the DMN and other networks in more severely impaired MCI subjects, parallel to the observed clinical benefits.

Indexed as

Alzheimer DiseaseCognitive DysfunctionBrainCognitive TrainingDefault Mode NetworkHumansMagnetic Resonance ImagingNerve NetAlzheimer’s diseasebiomarkersdefault mode networkdigital therapeuticsfunctional MRImild cognitive impairmentneuroplasticity

Identifiers

PMID36442202
PMCPMC9881022
OpenAlexW4310044999

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.