Evidence map›Paper›PMID 36442199›Full record

Trial reportJournal of Alzheimer's disease : JAD2023

Mindfulness Prevents Depression and Psychopathology in Elderly People with Mild to Moderate Alzheimer's Disease: A Randomized Clinical Trial.

Domingo J Quintana-Hernández, Jaime Rojas-Hernández, Angelo Santana-Del Pino, Carmen Céspedes Suárez, Mónica Pellejero Silva, María Teresa Miró-Barrachina, Ignacio Ibáñez Fernández, José Antonio Estupiñán López, Lucas F Borkel

Abstract readRandomized Controlled TrialEquivalence Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of Alzheimer's disease : JAD, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Domingo J Quintana-HernándezDepartment of Psychology, Atlántico Medio University, Tafira Baja, Spain.
Jaime Rojas-HernándezAsociación Canaria para el Desarrollo de la Salud a través de la Atención, Las Palmas de Gran Canaria, Spain.
Angelo Santana-Del PinoDepartment of Mathematics, Las Palmas de Gran Canaria University, Las Palmas de Gran Canaria, Spain.
Carmen Céspedes SuárezDepartment of Psychology, Atlántico Medio University, Tafira Baja, Spain.
Mónica Pellejero SilvaDepartment of Communication, Atlántico Medio University, Tafira Baja, Spain.
María Teresa Miró-BarrachinaDepartment of Clinical Psychology, Psychobiology and Methodology, La Laguna University, La Laguna, Spain.
Ignacio Ibáñez FernándezDepartment of Clinical Psychology, Psychobiology and Methodology, La Laguna University, La Laguna, Spain.
José Antonio Estupiñán LópezAsociación Canaria para el Desarrollo de la Salud a través de la Atención, Las Palmas de Gran Canaria, Spain.
Lucas F BorkelAsociación Científica Psicodélica, Las Palmas de Gran Canaria, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis longitudinal study addressed whether mindfulness practice prevents psychological and behavioral symptoms, especially mood disorders, in Alzheimer's disease (AD).

objectiveTo assess the incidence of depression in the course of AD and to determine which non-pharmacological treatment (NPT) is most effective in preventing psychopathological symptoms.

methodsWe conducted a longitudinal, non-inferiority and equivalence randomized clinical trial, repeated-measures design, with a control group and three experimental treatments: mindfulness, cognitive stimulation, and relaxation. Each experimental group performed three weekly sessions for two years. The pharmacological treatment of all participants was donepezil (10 mg). Participants were patients with probable AD without diagnosed depression from the public neurology services of the Canary Health Service, Spain. Psychological evaluation was performed using the Geriatric Depression Scale (GDS), Hamilton Depression Rating Scale (HDRS), and Neuropsychiatric Inventory (NPI-Q). The statistical analysis included only patients who attended at least 75% of the sessions. A nonparametric, repeated-measures analysis was performed with Kruskal-Wallis H test and between-group differences with Mann-Whitney U test with Bonferroni correction (p < 0.008). Effect size was calculated with partial eta-squared.

resultsThe results showed significant differences with large effect sizes (η2p>0.14) between mindfulness and the rest of the experimental groups as well as the control in the GDS, HDRS, and NPI-Q scales.

conclusionCompared to the other experimental groups, only mindfulness prevented the onset of depression and other psychopathologies in early-stage AD. Based on its effectiveness in maintaining cognitive functions and preventing psychopathology, we recommend mindfulness as the first-choice NPT for mild to moderate AD.

Indexed as

Alzheimer DiseaseMindfulnessAgedDepressionDonepezilHumansLongitudinal StudiesDonepezilAlzheimer’s diseasecognitive stimulationmindfulnessrandomized clinical trialrelaxation

Identifiers

PMID36442199
PMCPMC9881020

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.