ArticleProceedings of the National Academy of Sciences of the United States of America2022
Spatial contextual recognition memory updating is modulated by dopamine release in the dorsal hippocampus from the locus coeruleus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 56 citations in OpenAlex.
- Neurotransmitters in memory destabilization: An integrative perspective framed by prediction error and novelty.Cognitive, affective & behavioral neuroscience · 2026Review
- Subcellular Localization of Dopamine D1 and D2 Receptors in the Mouse Hippocampus.The Journal of comparative neurology · 2026Article
- Old mice fail to integrate a memory update into an existing hippocampal engram.bioRxiv : the preprint server for biology · 2026Article
- Altered molecular signaling pathways in the hippocampus of rhesus monkeys following chronic alcohol use.Scientific reports · 2026Article
- Photostimulation of locus coeruleus CA1 catecholaminergic terminals reversed Spatial memory impairment in an alzheimer's disease mouse model.Psychopharmacology · 2026Article
- Relation between Cerebrospinal Fluid Catecholamines and Vascular Risk Factors, Thyroid Function and Vitamins in Healthy Individuals and Patients with Neurodegenerative Diseases.Current Alzheimer research · 2026Observational
- Long-Term Memory Updating Parallels Altered Awake and Sleep Hippocampal Replays.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The relevance of context in memory tasks influences the magnitude of hippocampal remapping.Cell reports · 2025Article
- Article
- Sex-dimorphic oxytocin regulation of CA1-dependent spatial memory and synaptic plasticity in juvenile rats.Behavioral and brain functions : BBF · 2025Article
- Optogenetic stimulation of midbrain dopaminergic neurons rescues hippocampal synaptic plasticity deficits in a mouse model of Alzheimer's disease.Translational psychiatry · 2025Article
- Stimulus-Dependent Dopamine Dynamics from Locus Coeruleus Axons.bioRxiv : the preprint server for biology · 2025Article
- Dopamine System Dysfunction in Alzheimer's Disease.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2025Review
- Not the same as it ever was: A review of memory modification, updating, and distortion in humans and rodents.Neuroscience and biobehavioral reviews · 2025Review
- Functional and Regional Specificity of Noradrenergic Signaling for Encoding and Retrieval of Associative Recognition Memory in the Rat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- A superior colliculus-originating circuit prevents cocaine reinstatement via VR-based eye movement desensitization treatment.National science review · 2025Article
- Noradrenergic Locus Coeruleus-CA3 Activation Alleviates Neuropathic Pain and Anxiety- and Depression-Like Behaviors by Suppressing Microglial Neuroinflammation in SNI Mice.CNS neuroscience & therapeutics · 2025Article
- Repeated exposure to novelty promotes resilience against the amyloid-beta effect through dopaminergic stimulation.Psychopharmacology · 2025Article
- Astringent flavanol fires the locus-noradrenergic system, regulating neurobehavior and autonomic nerves.Current research in food science · 2025Article
- Time- and Region-specific Effect of Vortioxetine on Central LPS-induced Transcriptional Regulation of NLRP3 Inflammasome.Current neuropharmacology · 2025Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Detecting novelty is critical to consolidate declarative memories, such as spatial contextual recognition memory. It has been shown that stored memories, when retrieved, are susceptible to modification, incorporating new information through an updating process. Catecholamine release in the hippocampal CA1 region consolidates an object location memory (OLM). This work hypothesized that spatial contextual memory updating could be changed by decreasing catecholamine release in the hippocampal CA1 terminals from the locus coeruleus (LC). In a mouse model expressing Cre-recombinase under the control of the tyrosine hydroxylase (TH) promoter, memory updating was impaired by photoinhibition of the CA1 catecholaminergic terminals from the LC (LC-CA1) but not from the ventral tegmental area (VTA-CA1). In vivo microdialysis confirmed that the extracellular concentration of both dopamine (DA) and noradrenaline (NA) decreased after photoinhibition of the LC-CA1 terminals (but not VTA-CA1) during the OLM update session. Furthermore, DA D1/D5 and beta-adrenergic receptor antagonists disrupted behavior, but only the former impaired memory updating. Finally, photoinhibition of LC-CA1 terminals suppressed long-term potentiation (LTP) induction in Schaffer's collaterals as a plausible mechanism for memory updating. These data will help understand the underpinning mechanisms of DA in spatial contextual memory updating.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.