Evidence map›Paper›PMID 36442116›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Identification of aceNKPs, a committed common progenitor population of the ILC1 and NK cell continuum.

Noe Rodriguez-Rodriguez, Paula A Clark, Mayuri Gogoi, Ana C F Ferreira, Bernhard Kerscher, Alastair Crisp, Helen E Jolin, Jane E Murphy, Meera Sivasubramaniam, Luisa Pedro and 5 more

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 3 countries.

Noe Rodriguez-RodriguezMedical Research Council, Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.ORCID 0000-0001-7825-5634
Paula A ClarkMedical Research Council, Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.
Mayuri GogoiMedical Research Council, Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.
Ana C F FerreiraMedical Research Council, Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.
Bernhard KerscherPaul-Ehrlich-Institute, Federal Institute for Vaccines and Biomedicines, Langen 63225, Germany.ORCID 0000-0001-9300-7401
Alastair CrispMedical Research Council, Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.ORCID 0000-0001-8069-2294
Helen E JolinMedical Research Council, Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.
Jane E MurphyMedical Research Council, Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.ORCID 0000-0003-2201-9469
Meera SivasubramaniamMedical Research Council, Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.
Luisa PedroHutchison/MRC Research Centre, Cambridge CB2 0XZ, United Kingdom.
Jennifer A WalkerMedical Research Council, Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.ORCID 0000-0002-0488-3619
Morgan W D HeycockMedical Research Council, Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.
Jacqueline D ShieldsHutchison/MRC Research Centre, Cambridge CB2 0XZ, United Kingdom.
Jillian L BarlowMedical Research Council, Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.
Andrew N J McKenzieMedical Research Council, Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.
MRC Laboratory of Molecular Biology · GBHutchison/MRC Research Centre · GBUniversity of York · GB

Funding

Medical Research Council MC_U105178805Medical Research Council MC_UP_1101/2Medical Research Council MC_UU_12022/5Medical Research Council U105178805Wellcome Trust 100963Wellcome Trust 100963/Z/13/ZWellcome Trust 220223Wellcome Trust 220223/Z/20/Z
6 · The paper itself

Abstract

The development of innate lymphoid cell (ILC) transcription factor reporter mice has shown a previously unexpected complexity in ILC hematopoiesis. Using novel polychromic mice to achieve higher phenotypic resolution, we have characterized bone marrow progenitors that are committed to the group 1 ILC lineage. These common ILC1/NK cell progenitors (ILC1/NKP), which we call "aceNKPs", are defined as lineage

Indexed as

Immunity, InnateInterleukin-15AnimalsKiller Cells, NaturalMicePerforinRepressor ProteinsTranscription FactorsTumor Suppressor ProteinsBcl11b protein, mouseInterleukin-15PerforinRepressor ProteinsTranscription FactorsTumor Suppressor ProteinshematopoiesisILC1sinnate lymphoid cellsNK cellsNKG2A/C/E

Identifiers

PMID36442116
PMCPMC7614094
OpenAlexW4310466434

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.