ArticleProceedings of the National Academy of Sciences of the United States of America2022
Local production of corticotropin-releasing hormone in prefrontal cortex modulates male-specific novelty exploration.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 15 citations in OpenAlex.
- Early adversity promotes adolescent avoidance behavior by enhancing prefrontal-amygdala communication through CRHbioRxiv : the preprint server for biology · 2026Article
- Stress-induced motivational impairment is marked by diminished frontocortical cellular communication and neuropeptide signaling.bioRxiv : the preprint server for biology · 2026Article
- Synaptic, cellular, and circuit mechanisms underlying sex differences in behaviors.Biology of sex differences · 2026Review
- Medial prefrontal cortex neurons integrate amygdala and hypothalamic oxytocin signals to mediate stress-induced social alterations.Communications biology · 2026Article
- Pre-trauma cognitive traits predict fear generalization and associated prefrontal functioning in a longitudinal rodent model.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Polychlorinated Biphenyls, Oxidative Stress, and Brain Health: Mechanistic Links to Neurodegenerative and Neurodevelopmental Diseases.Antioxidants (Basel, Switzerland) · 2026Review
- Prefrontal corticotropin-releasing factor promotes resilience to social stress.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Treadmill exercise prevents stress-induced anxiety-like behaviors via enhancing the excitatory input from the primary motor cortex to the thalamocortical circuit.Nature communications · 2025Article
- Cortical arealization of interneurons defines shared and distinct molecular programs in developing human and macaque brains.Nature communications · 2025Article
- Functional and morphological adaptation of medial prefrontal corticotropin releasing factor receptor 1-expressing neurons in male mice following chronic ethanol exposure.Neurobiology of stress · 2024Article
- Genetic approaches to elucidating cortical and hippocampal GABAergic interneuron diversity.Frontiers in cellular neuroscience · 2024Review
- ATF6β Deficiency Elicits Anxiety-like Behavior and Hyperactivity Under Stress Conditions.Neurochemical research · 2023Article
- Understanding the habenula: A major node in circuits regulating emotion and motivation.Pharmacological research · 2023Review
- The role of the prefrontal cortex in social interactions of animal models and the implications for autism spectrum disorder.Frontiers in psychiatry · 2023Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Neuromodulatory substances can be released from distal afferents for communication between brain structures or produced locally to modulate neighboring circuit elements. Corticotropin-releasing hormone (CRH) from long-range neurons in the hypothalamus projecting to the medial prefrontal cortex (mPFC) has been shown to induce anxiety-like behaviors. However, the role of CRH produced in the mPFC has not been investigated. Here we demonstrate that a specific class of mPFC interneurons that express CRH (CrhINs) releases CRH upon high-frequency stimulation to enhance excitability of layer 2/3 pyramidal cells (L2/3 PCs) expressing the CRH receptors. When stimulated at low frequency, CrhINs release GABA resulting in the inhibition of oxytocin receptor-expressing interneurons (OxtrINs) and L2/3 PCs. Conditional deletion of CRH in mPFC CrhINs and chemogenetic activation of CrhINs have opposite effects on novelty exploration in male but not in female mice, and do not affect anxiety-related behaviors in either males or females. Our data reveal that CRH produced by local interneurons in the mPFC is required for sex-specific novelty exploration and suggest that our understanding of complex behaviors may require knowledge of local and remote neuromodulatory action.
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