Evidence map›Paper›PMID 36442007›Full record

ArticleNeuropsychology2023

Past and future episodic detail retrieval is reduced among clinically normal older adults at higher genetic risk for late-onset Alzheimer's disease.

Mónica C Acevedo-Molina, Sean C Thayer, Kiley Horn, Hanna Nkulu, Lee Ryan, Jessica R Andrews-Hanna, Matthew D Grilli

Open access · hybridAbstract read
In one paragraph

Article in Neuropsychology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

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  10. Episodic recombination and the role of time in mental travel.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Mónica C Acevedo-MolinaPsychology Department, University of Arizona.ORCID 0000-0003-3835-0391
Sean C ThayerPsychology Department, University of Arizona.
Kiley HornPsychology Department, University of Arizona.
Hanna NkuluPsychology Department, University of Arizona.
Lee RyanPsychology Department, University of Arizona.
Jessica R Andrews-HannaPsychology Department, University of Arizona.
Matthew D GrilliPsychology Department, University of Arizona.
University of Arizona · US

Funding

Alzheimer's Prevention Initiative APOE4 TrialUF1AG046150 · NIA · BANNER ALZHEIMER'S INSTITUTE · PI REIMAN, ERIC MICHAEL, TARIOT, PIERRE N. · 2013 to 2013
$33.3M
The episodic autobiographical memory hypothesis of preclinical Alzheimer's disease: Developing a new approach for early cognitive detection and measurement of Alzheimer's diseaseR03AG060271 · NIA · UNIVERSITY OF ARIZONA · PI GRILLI, MATTHEW D · 2019 to 2020
$154k
Aging and Autobiographical Memory in Bilingual and Monolingual Hispanics.F31AG069443 · NIA · UNIVERSITY OF ARIZONA · PI ACEVEDO MOLINA, MONICA · 2020 to 2022
$98k
NIA NIH HHS F31 AG069443NIA NIH HHS R03 AG060271NIA NIH HHS UF1 AG046150NIH HHS
6 · The paper itself

Abstract

objectiveRemembering and imagining personal events that are rich in episodic (i.e., event-specific) detail is compromised in older adults who have mild cognitive impairment, a known risk factor for Alzheimer's disease dementia. Less clear is whether lower episodic detail generation is associated with higher risk for Alzheimer's disease dementia before mild clinical decline is detectable.

methodWe compared past and future autobiographical thinking in clinically normal older adult carriers of the Alzheimer's disease-associated apolipoprotein E e4 allele (APOE4;

resultsAPOE4 carriers showed a significant reduction for episodic details when remembering past events (

conclusionsThese findings suggest that APOE4 is associated with a selective reduction of episodic detail during past and future autobiographical thinking among clinically normal older adults. Reduced episodic detail generation, therefore, may be an early cognitive associate of higher risk for Alzheimer's disease dementia. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Indexed as

Alzheimer DiseaseCognitive DysfunctionMemory, EpisodicAgedApolipoprotein E4ForecastingHumansRisk FactorsApolipoprotein E4

Identifiers

PMID36442007
PMCPMC10129290
OpenAlexW4310149556

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.