Evidence map›Paper›PMID 36441479›Full record

ArticleMolecular neurobiology2023

A Push-Pull Mechanism Between PRRT2 and β4-subunit Differentially Regulates Membrane Exposure and Biophysical Properties of NaV1.2 Sodium Channels.

Pierluigi Valente, Antonella Marte, Francesca Franchi, Bruno Sterlini, Silvia Casagrande, Anna Corradi, Pietro Baldelli, Fabio Benfenati

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Pierluigi ValenteDepartment of Experimental Medicine, Section of Physiology, University of Genova, Viale Benedetto XV, 3, 16132, Genova, Italy. pierluigi.valente@unige.it.ORCID http://orcid.org/0000-0001-6272-1821
Antonella MarteDepartment of Experimental Medicine, Section of Physiology, University of Genova, Viale Benedetto XV, 3, 16132, Genova, Italy.
Francesca FranchiDepartment of Experimental Medicine, Section of Physiology, University of Genova, Viale Benedetto XV, 3, 16132, Genova, Italy.
Bruno SterliniDepartment of Experimental Medicine, Section of Physiology, University of Genova, Viale Benedetto XV, 3, 16132, Genova, Italy.
Silvia CasagrandeDepartment of Experimental Medicine, Section of Physiology, University of Genova, Viale Benedetto XV, 3, 16132, Genova, Italy.
Anna CorradiDepartment of Experimental Medicine, Section of Physiology, University of Genova, Viale Benedetto XV, 3, 16132, Genova, Italy.
Pietro BaldelliDepartment of Experimental Medicine, Section of Physiology, University of Genova, Viale Benedetto XV, 3, 16132, Genova, Italy.
Fabio BenfenatiIRCCS, Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132, Genova, Italy. fabio.benfenati@iit.it.ORCID http://orcid.org/0000-0002-0653-8368
Ospedale Policlinico San Martino · ITItalian Institute of Technology · ITUniversity of Genoa · IT

Funding

Compagnia di San Paolo 2015.0546Compagnia di San Paolo 2017.20612Fondazione Telethon GGP19120IRCCS Ospedale Policlinico San Martino 5x1000Ministero dell'Istruzione, dell'Università e della Ricerca 2017-A9MK4RMinistero dell'Istruzione, dell'Università e della Ricerca 2020-WMSNBL
6 · The paper itself

Abstract

Proline-rich transmembrane protein 2 (PRRT2) is a neuron-specific protein implicated in the control of neurotransmitter release and neural network stability. Accordingly, PRRT2 loss-of-function mutations associate with pleiotropic paroxysmal neurological disorders, including paroxysmal kinesigenic dyskinesia, episodic ataxia, benign familial infantile seizures, and hemiplegic migraine. PRRT2 is a negative modulator of the membrane exposure and biophysical properties of Na

Indexed as

Membrane ProteinsNAV1.2 Voltage-Gated Sodium ChannelNerve Tissue ProteinsNeuronsAtaxiaBrainHumansMutationNervous System DiseasesMembrane ProteinsNAV1.2 Voltage-Gated Sodium ChannelNerve Tissue ProteinsPRRT2 protein, humanIntrinsic excitabilityPersistent Na+ currentProline-rich transmembrane protein 2Resurgent Na+ currentTransient Na+ current

Identifiers

PMID36441479
PMCPMC9899197
OpenAlexW4310179112

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.