Evidence map›Paper›PMID 36441429›Full record

ArticleJournal of autism and developmental disorders2024

Latent Class Analysis Identifies Distinctive Behavioral Subtypes in Children with Fragile X Syndrome.

Walter E Kaufmann, Melissa Raspa, Carla M Bann, Julia M Gable, Holly K Harris, Dejan B Budimirovic, Reymundo Lozano, FORWARD Consortium

Open access · greenAbstract read
In one paragraph

Article in Journal of autism and developmental disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Profile of Behavioral Comorbidities in Children With Fragile X Syndrome.Journal of autism and developmental disorders · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Walter E KaufmannDepartment of Human Genetics, Emory University School of Medicine, 615 Michael Street, Atlanta, GA, 30322, USA. walter.e.kaufmann@emory.edu.ORCID http://orcid.org/0000-0002-8561-8453
Melissa RaspaRTI International, 3040 Cornwallis Road, Research Triangle Park, NC, 27709, USA.
Carla M BannRTI International, 3040 Cornwallis Road, Research Triangle Park, NC, 27709, USA.
Julia M GableRTI International, 3040 Cornwallis Road, Research Triangle Park, NC, 27709, USA.
Holly K HarrisTexas Children's Hospital, 8080 North Stadium Drive, Houston, TX, 77054, USA.
Dejan B BudimirovicKennedy Krieger Institute, 1741 Ashland Avenue, Baltimore, MD, 21205, USA.
Reymundo LozanoIcahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY, 10029, USA.
FORWARD Consortium
RTI International · USEmory University · USKennedy Krieger Institute · USTexas Children's Hospital · USIcahn School of Medicine at Mount Sinai · US

Funding

Cooperative Agreement for a Nat'l Research & Training Org for People with DevelopU01DD000231 · DD · ASSN OF UNIVERSITY CENTERS/ DISABILITIES · PI JESIEN, GEORGE S. · 2007 to 2012
$16.8M
Pilot Longitudinal Data Collection to Inform Public Health_Fragile X SyndromeU19DD000753 · DD · INSTITUTE FOR BASIC RES IN DEV DISABIL · PI BROWN, WILLIAM TED · 2011 to 2014
$2.3M
Using Longitudinal Data to Characterize the Natural History of Fragile X Syndrome--Component AU01DD001189 · DD · INSTITUTE FOR BASIC RES IN DEV DISABIL · PI VELINOV, MILEN T · 2015 to 2019
$1.7M
FXTAS Key Molecular Pathways Converge with Other Neurodegenerative DisordersK01NS126736 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Reymundo Lozano · 2022 to 2026
$1.4M
ACL HHS U01DD001189NCBDD CDC HHS contract 75D30120F09737NCBDD CDC HHS U01 DD000231NCBDD CDC HHS U01DD000231NCBDD CDC HHS # U01DD001189NCBDD CDC HHS U01 DD001189NCBDD CDC HHS #U19DD000753NCBDD CDC HHS U19 DD000753NINDS NIH HHS K01 NS126736
6 · The paper itself

Abstract

Fragile X syndrome (FXS) is characterized by variable neurobehavioral abnormalities, which leads to difficulties in developing and evaluating treatments and in determining accurate prognosis. We employed a pediatric cross-sectional sample (1,072 males, 338 females) from FORWARD, a clinic-based natural history study, to identify behavioral subtypes by latent class analysis. Input included co-occurring behavioral conditions, sleep and sensory problems, autistic behavior scales (SCQ, SRS-2), and the Aberrant Behavior Checklist revised for FXS (ABC

Indexed as

Autism Spectrum DisorderFragile X SyndromeChildCross-Sectional StudiesFemaleHumansLatent Class AnalysisMaleSocial BehaviorAutism symptomatologyFragile X syndromeIntellectual disabilityLatent class analysisMaladaptive behaviorPhenotypes

Identifiers

PMID36441429
PMCPMC10258834
OpenAlexW4310213303

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.