Evidence map›Paper›PMID 36441391›Full record

ArticleJournal of applied genetics2023

Non-mosaic X monosomy (77,X) in a female dog with signs of virilization.

Izabela Szczerbal, Emilian Malek, Antonella Rigillo, Anna Lukomska, Kamil Kacprzak, Stefania Gasparini, Joanna Nowacka-Woszuk, Monika Stachowiak, Mehmet O Aksoy, Marek Switonski

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Izabela SzczerbalDepartment of Genetics and Animal Breeding, Poznan University of Life Sciences, Wolynska 33, 60-637, Poznan, Poland.
Emilian MalekDepartment of Preclinical Sciences and Infectious Diseases, Poznan University of Life Sciences, Poznan, Poland.
Antonella RigilloPathology Division, San Marco Veterinary Clinic and Laboratory, Veggiano, Italy.
Anna LukomskaDepartment of Preclinical Sciences and Infectious Diseases, Poznan University of Life Sciences, Poznan, Poland.
Kamil KacprzakDepartment of Small Animal Diseases and Clinic, Institute of Veterinary Medicine, Warsaw University of Life Sciences, Warsaw, Poland.
Stefania GaspariniPathology Division, San Marco Veterinary Clinic and Laboratory, Veggiano, Italy.
Joanna Nowacka-WoszukDepartment of Genetics and Animal Breeding, Poznan University of Life Sciences, Wolynska 33, 60-637, Poznan, Poland.
Monika StachowiakDepartment of Genetics and Animal Breeding, Poznan University of Life Sciences, Wolynska 33, 60-637, Poznan, Poland.
Mehmet O AksoyDepartment of Genetics and Animal Breeding, Poznan University of Life Sciences, Wolynska 33, 60-637, Poznan, Poland.
Marek SwitonskiDepartment of Genetics and Animal Breeding, Poznan University of Life Sciences, Wolynska 33, 60-637, Poznan, Poland. marek.switonski@up.poznan.pl.ORCID http://orcid.org/0000-0003-2539-9508
University of Life Sciences in Poznań · PLVeterinary Oncological Center · ITWarsaw University of Life Sciences · PL

Funding

Faculty of Veterinary Medicine and Animal Science, Poznań University of Life Sciences 506.534.05.00
6 · The paper itself

Abstract

A 14-month-old female Miniature Poodle dog with an enlarged clitoris and asymmetry in the placement of the teats was subjected to clinical, histopathological, and genetic studies. Macroscopically, the uterus and fallopian tubes appeared normal, while both ovaries were diffusely altered. At histology, the ovarian parenchyma was almost completely effaced by a diffuse hyperplasia of theca cells with atretic primary follicles. Chromosome analysis showed pure (non-mosaic) X monosomy (77,X). This finding was confirmed by the highly sensitive droplet digital PCR (ddPCR) approach. Despite the observed virilization, molecular analysis did not show the presence of Y-linked genes (SRY, ZFY, and TSPY1) in the blood cells or ovary tissue. To the best of our knowledge, this is the first case of X monosomy in a dog associated with virilization.

Indexed as

MonosomyVirilismAnimalsCell Cycle ProteinsDogsFemaleHumansPolymerase Chain ReactionX ChromosomeCell Cycle ProteinsTSPY1 protein, humanAneuploidyDisorders of sex developmentIntersexualitySex chromosomes

Identifiers

PMID36441391
PMCPMC9836978
OpenAlexW4310103504

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.