Evidence map›Paper›PMID 36441276›Full record

ArticlePediatric surgery international2022

Effects of extensive mobilization and tension anastomosis in anorectal reconstruction (experimental study).

Dmitrii Morozov, Olga Morozova, Lubov Severgina, Olga Mokrushina, Tatyana Marchuk, Ivan Budnik, Hüseyin Özbey, Dmitry Morozov

Abstract read
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In one paragraph

Article in Pediatric surgery international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Dmitrii MorozovDepartment of Pediatric Surgery, Faculty of Pediatrics, Pirogov Russian National Research Medical University, 1 Ostrovityanova Street, 117997, Moscow, Russia. mr.morozovy@mail.ru.
Olga MorozovaDepartment of Pathophysiology, Sechenov University, 8 Trubetskaya Street, 119991, Moscow, Russia.
Lubov SeverginaDepartment of Pathological Anatomy, Sechenov University, 8 Trubetskaya Street, 119991, Moscow, Russia.
Olga MokrushinaDepartment of Pediatric Surgery, Faculty of Pediatrics, Pirogov Russian National Research Medical University, 1 Ostrovityanova Street, 117997, Moscow, Russia.
Tatyana MarchukDepartment of Pediatric Surgery and Urology-Andrology, Sechenov University, 8 Trubetskaya Street, 119991, Moscow, Russia.
Ivan BudnikDepartment of Pathophysiology, Sechenov University, 8 Trubetskaya Street, 119991, Moscow, Russia.
Hüseyin ÖzbeyDepartment of Pediatric Surgery and Urology-Andrology, Sechenov University, 8 Trubetskaya Street, 119991, Moscow, Russia.
Dmitry MorozovDepartment of Pediatric Surgery and Urology-Andrology, Sechenov University, 8 Trubetskaya Street, 119991, Moscow, Russia.
Sechenov University · RUPirogov Russian National Research Medical University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAnorectoplasty and pull-through procedure can be performed with extensive mobilization or tension anastomosis, which can compromise bowel blood perfusion. We aimed to analyze the hypoxia biomarker values and histopathological findings in both conditions to correlate the occurrence of anal stenosis and defecation disorders in experimental models.

methodsWe created anorectal reconstruction models with impaired vascularization of the anorectum (group I) and tension anastomosis (group II) in rats. A third group of animals underwent sham operation (group III) and another as controls (group IV). Hypoxia biomarker values were assessed in all groups. The histopathological changes on the postoperative days 3 and 35, anal stenosis and defecation disorders on day 35 were compared.

resultsHypoxia biomarker values confirmed postoperative ischemia in groups I-III compared to control. Group I and II rats had a similarly pronounced ischemia with histopathologic changes in the anorectum on the postoperative day 3 and accompanied by severe fibrosis on day 35. Compared to the sham operation, both groups showed defecation disorders with significant anal stenoses.

conclusionExtensive rectal mobilization to about the same extent as tension anastomosis has a major impact on postoperative rectal ischemia, resulting in severe fibrotic changes in the anorectum and defecation disorders in the long term.

Indexed as

Anorectal MalformationsIntestine, LargeAnastomosis, SurgicalAnimalsConstriction, PathologicHypoxiaRatsAnal stenosisAnorectal malformationAnorectoplastyConstipationHirschsprung’s diseaseIschemiaTension anastomosis

Identifiers

PMID36441276
OpenAlexW4310136347

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.