Evidence map›Paper›PMID 36441265›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2023

Demethylation of CADM1 and SOCS1 using capsaicin in cervical cancer cell line.

Mahek Sharan, Meenakshi Jha, Rishima Chandel, Saima Syeda, Runjhun Mathur, Niraj Kumar Jha, Saurabh Kumar Jha, Harsh Goel, Anju Shrivastava, Sushma Chauhan and 2 more

Abstract read
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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. DNMT Enzymes and Their Impact on Cervical Cancer: A State-of-the-Art Review.International journal of molecular sciences · 2025
    Review
  3. Article
  4. Capsaicin: beyond TRPV1.Frontiers in nutrition · 2025
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Mahek SharanDepartment of Zoology, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
Meenakshi JhaDepartment of Biotechnology, Amity University, Raipur, Chhattisgarh, India.
Rishima ChandelDepartment of Zoology, Delhi University, Delhi, India.
Saima SyedaDepartment of Zoology, Delhi University, Delhi, India.
Runjhun MathurA.P.J Abdul Kalam University, Lucknow, Uttar Pradesh, India.
Niraj Kumar JhaDepartment of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida, Uttar Pradesh, 201310, India.
Saurabh Kumar JhaDepartment of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida, Uttar Pradesh, 201310, India.
Harsh GoelLaboratory of the Oncology Unit, Dr. B.R.A, Institute Rotary Cancer Hospital, AIIMS, Delhi, India.
Anju ShrivastavaDepartment of Zoology, Delhi University, Delhi, India.
Sushma ChauhanDepartment of Biotechnology, Amity University, Raipur, Chhattisgarh, India.
Sudheer PamidimarriDepartment of Molecular Biology and Genetics, Gujarat Biotechnology University, Gandhinagar, Gujarat, India.
Abhimanyu Kumar JhaDepartment of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida, Uttar Pradesh, 201310, India. drabhimanyukumarjha@gmail.com.
Sharda University · INUniversity of Delhi · INDr. A.P.J. Abdul Kalam Technical University · INDR. B.R.A. Institute Rotary Cancer Hospital · INGujarat University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cervical cancer is one of the leading causes of women's mortality in developing countries. The prevalence of cervical cancer is higher in developing countries like India and continents like Africa. Hyper-methylation of tumor suppressor genes through human papillomavirus (HPV) infection is known to be one of the major causes of cervical cancer. The promoter hypermethylation of the cell adhesion molecule 1 (CADM1) and suppressor of cytokine signalling (SOCS1) genes due to DNMT1 overexpression leads to their epigenetic silencing followed by gene repression causing cervical cancer. In silico study on the inhibition effect of capsaicin on DNMT1 was simulated by different servers. The binding energy was observed to be -7.8 kcal/mol. In vitro studies on the effect of capsaicin on aberrant methylation of CADM1 and SOCS1 were performed on the adenocarcinoma cervical cancer cell line, HeLa. The IC

Indexed as

Uterine Cervical NeoplasmsCapsaicinCell Adhesion Molecule-1Cell Line, TumorDemethylationDNA MethylationFemaleHeLa CellsHumansSuppressor of Cytokine Signaling 1 ProteinSuppressor of Cytokine Signaling ProteinsCADM1 protein, humanCapsaicinCell Adhesion Molecule-1SOCS1 protein, humanSuppressor of Cytokine Signaling 1 ProteinSuppressor of Cytokine Signaling ProteinsCapsaicinCervical cancerEpigenetic modificationsPromoter hypermethylationTumor suppressor genes

Identifiers

PMID36441265
OpenAlexW4310211228

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.