Evidence map›Paper›PMID 36441237›Full record

ArticleSkeletal radiology2023

Detection of bone marrow metastases in children and young adults with solid cancers with diffusion-weighted MRI.

Ali Rashidi, Lucia Baratto, Praveen Jayapal, Ashok Joseph Theruvath, Elton Benjamin Greene, Rong Lu, Sheri L Spunt, Heike E Daldrup-Link

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Skeletal radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ali RashidiDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA, USA.
Lucia BarattoDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA, USA.
Praveen JayapalDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA, USA.
Ashok Joseph TheruvathDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA, USA.
Elton Benjamin GreeneDepartment of Radiology, Pediatric Radiology, Lucile Packard Children's Hospital, Stanford University School of Medicine, Stanford, CA, USA.
Rong LuQuantitative Sciences Unit, Stanford University School of Medicine, Stanford, CA, USA.
Sheri L SpuntDepartment of Pediatrics, Hematology/Oncology, Stanford University School of Medicine, Stanford, CA, USA.
Heike E Daldrup-LinkDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA, USA. H.E.Daldrup-Link@stanford.edu.ORCID http://orcid.org/0000-0002-4929-819X
Stanford University · USLucile Packard Children's Hospital · US

Funding

Translational Oncology Research Program (Project-005)P30CA124435 · NCI · STANFORD UNIVERSITY · PI Vittorio Sebastiano · 2007 to 2026
$71.4M
Advanced Imaging Tools to Assess Cancer Therapeutics in Pediatric PatientsR01CA269231 · NCI · STANFORD UNIVERSITY · PI Heike Elizabeth Daldrup-Link · 2022 to 2026
$3.5M
Personalized Whole Body Staging for Children with Cancer: A Solution to the Conundrum of Long-Term Side Effects from CT and PET/CT ScansR01HD081123 · NICHD · STANFORD UNIVERSITY · PI DALDRUP-LINK, HEIKE ELIZABETH · 2015 to 2019
$2.5M
NCI NIH HHS P30 CA124435NCI NIH HHS R01 CA269231NICHD NIH HHS R01 HD081123
6 · The paper itself

Abstract

objectiveTo compare the diagnostic accuracy of diffusion-weighted (DW)-MRI with b-values of 50 s/mm

methodsIn an institutional review board-approved prospective study, we performed 51 whole-body DW-MRI scans in 19 children and young adults (14 males, 5 females; age range: 1-25 years) with metastasized cancers before (n = 19 scans) and after (n = 32 scans) chemotherapy. Two readers determined the presence of focal bone marrow lesions in 10 anatomical areas. A third reader measured ADC and SNR of focal lesions and normal marrow. Simultaneously acquired

resultsThe SNR of bone marrow metastases was significantly higher compared to normal bone marrow on b = 50 s/mm

conclusionBone marrow metastases in children and young adults can be equally well detected on b = 50 s/mm

Indexed as

Bone Marrow NeoplasmsBone NeoplasmsAdolescentAdultBone MarrowChildChild, PreschoolDiffusion Magnetic Resonance ImagingFemaleHumansInfantMaleProspective StudiesYoung AdultApparent diffusion coefficientBone marrow metastasesb valueChildrenDW-MRI

Identifiers

PMID36441237
PMCPMC10757820
OpenAlexW4310117566

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.