ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2023
Biomechanical properties analysis of forme fruste keratoconus and subclinical keratoconus.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Wavelet time-frequency analysis enhances noise-resilient quantification of corneal wave velocity and natural frequency in optical coherence elastography.Biomedical optics express · 2026Article
- Analysis of astigmatism type influence onFrontiers in bioengineering and biotechnology · 2026Article
- The Effects of Eye Rubbing on Corneal Topography and Biomechanics in Children With Allergic Conjunctivitis.Translational vision science & technology · 2025Observational
- Early diagnosis of keratoconus using corneal biomechanics and OCT derived technologies.Eye and vision (London, England) · 2025Review
- Correlation of tear cortisol levels with morphological and biomechanical parameters of keratoconus.Frontiers in medicine · 2025Article
- Development and validation of the VAE-NT index: a novel biomechanical parameter for distinguishing subclinical corneal abnormalities.Frontiers in bioengineering and biotechnology · 2025Article
- Advances in Corneal Diagnostics Using Machine Learning.Bioengineering (Basel, Switzerland) · 2024Article
- Visual rehabilitation using rigid gas permeable contact lenses after femtosecond laser-assisted minimally invasive lamellar keratoplasty in patients with keratoconus.Scientific reports · 2024Article
- Comparison of the quantitative contrast sensitivity function between early keratoconus and normal eyes.BMC ophthalmology · 2024Article
- Comparison of a Scheimpflug imaging with other screening indices in diagnosing keratoconus and keratoconus suspect.Scientific reports · 2024Article
- Responsive porous microneedles with riboflavin ocular microinjection capability for facilitating corneal crosslinking.Journal of nanobiotechnology · 2024Article
- Biomechanical properties measured with dynamic Scheimpflug analyzer in central serous chorioretinopathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- Multi-modal imaging for the detection of early keratoconus: a narrative review.Eye and vision (London, England) · 2024Review
- Longitudinal Analysis of Corneal Biomechanics of Suspect Keratoconus: A Prospective Case-Control Study.Bioengineering (Basel, Switzerland) · 2024Article
- Corneal biomechanics in early diagnosis of keratoconus using artificial intelligence.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
purposeTo analyze the biomechanical properties of the eye in patients with unilateral keratoconus with normal (forme fruste keratoconus [FFKC]) or abnormal topography (subclinical keratoconus [SKC]).
methodsThis study included 153 eyes of 153 participants, including 95 eyes of patients with unilateral keratoconus, and 58 eyes of 58 healthy controls. Contralateral eyes with unilateral keratoconus were divided into two groups according to clinical manifestations and global consensus: FFKC (n = 30) and SKC (n = 65). The biomechanical characteristics were analyzed using non-parametric tests; further analysis thereof was performed after adjusting for confounding factors (i.e., intraocular pressure, age, and corneal thickness). Receiver operating characteristic curve (ROC) was used to analyze the ability of the biomechanical parameters to distinguish FFKC from SKC.
resultsStatistically significant differences between the FFKC and SKC groups were found in 9 of the 18 corneal biomechanical parameters analyzed using non-parametric tests. After adjusting for confounding factors, the multivariate analysis still revealed significant statistical differences in A1-time (P = 0.017), integrated radius (IR) (P = 0.024), and tomographic and biomechanical index (TBI, P < 0.001) between the FFKC and SKC groups. Stiffness parameter at first applanation (SP-A1) (Area under ROC [AUROC] = 0.765) demonstrated the strongest distinguishing ability, except for TBI (AUROC = 0.858) and Corvis Biomechanical Index (AUROC = 0.849), however, there was no statistically significant difference in SP-A1 (P = 0.366) between FFKC and SKC.
conclusionsBiomechanical parameters A1-time and IR have a high diversity between FFKC and SKC, besides TBI, and may reflect more subtle changes in corneal biomechanical properties (BPs) preceding SP-A1. The BPs of SKC are weaker than FFKC, which might be a basic and clue for the classification and diagnosis of the severity of early keratoconus in terms of biomechanics.
Indexed as
Identifiers
36441226What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.