Evidence map›Paper›PMID 36440858›Full record

ReviewAmerican journal of physiology. Cell physiology2023

Emerging vascular cell-specific roles for mineralocorticoid receptor: implications for understanding sex differences in cardiovascular disease.

Nicole L Wolter, Iris Z Jaffe

Open access · greenAbstract readReview
In one paragraph

Review in American journal of physiology. Cell physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Adverse Effects of Aldosterone: Beyond Blood Pressure.Journal of the American Heart Association · 2024
    Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Nicole L WolterMolecular Cardiology Research Institute, https://ror.org/002hsbm82Tufts Medical Center, Boston, Massachusetts.ORCID 0000-0001-9805-1380
Iris Z JaffeMolecular Cardiology Research Institute, https://ror.org/002hsbm82Tufts Medical Center, Boston, Massachusetts.ORCID 0000-0001-9300-1253
Tufts Medical Center · USTufts University · US

Funding

The Role of Vascular MR-Regulated Genes in Vascular Function and DiseaseR01HL095590 · NHLBI · TUFTS MEDICAL CENTER · PI Iris Z Jaffe · 2009 to 2026
$7.7M
Smooth Muscle Mineralocorticoid Receptors in Vascular Aging and HypertensionR01HL119290 · NHLBI · TUFTS MEDICAL CENTER · PI Iris Z Jaffe · 2014 to 2026
$7.0M
Research Training Program in Nutrition, Obesity and Metabolic DisordersT32DK124170 · NIDDK · TUFTS UNIVERSITY BOSTON · PI GREENBERG, ANDREW S · 2020 to 2024
$870k
NHLBI NIH HHS R01 HL095590NHLBI NIH HHS R01 HL119290NIDDK NIH HHS T32 DK124170
6 · The paper itself

Abstract

As growing evidence implicates extrarenal mineralocorticoid receptor (MR) in cardiovascular disease (CVD), recent studies have defined both cell- and sex-specific roles. MR is expressed in vascular smooth muscle (SMC) and endothelial cells (ECs). This review integrates published data from the past 5 years to identify novel roles for vascular MR in CVD, with a focus on understanding sex differences. Four areas are reviewed in which there is recently expanded understanding of the cell type- or sex-specific role of MR in

Indexed as

Cardiovascular DiseasesReceptors, MineralocorticoidRenal Insufficiency, ChronicEndothelial CellsFemaleHumansHypertension, PulmonaryInflammationMaleMineralocorticoid Receptor AntagonistsObesitySex CharacteristicsMineralocorticoid Receptor AntagonistsNR3C2 protein, humanReceptors, Mineralocorticoidatherosclerosismineralocorticoid receptorobesitypulmonary hypertensionsex differences

Identifiers

PMID36440858
PMCPMC9902217
OpenAlexW4310171519

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.