Evidence map›Paper›PMID 36440821›Full record

ReviewConnective tissue research2023

Formyl peptide receptors in bone research.

Mark A Lantieri, Jose R Perdomo Trejo, Quang Le, Abhijit Dighe, Quanjun Cui, Xinlin Yang

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Connective tissue research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Mark A LantieriDepartment of Orthopaedic Surgery, University of Virginia, Charlottesville, VA, USA.
Jose R Perdomo TrejoDepartment of Orthopaedic Surgery, University of Virginia, Charlottesville, VA, USA.
Quang LeDepartment of Orthopaedic Surgery, University of Virginia, Charlottesville, VA, USA.
Abhijit DigheDepartment of Orthopaedic Surgery, University of Virginia, Charlottesville, VA, USA.
Quanjun CuiDepartment of Orthopaedic Surgery, University of Virginia, Charlottesville, VA, USA.
Xinlin YangDepartment of Orthopaedic Surgery, University of Virginia, Charlottesville, VA, USA.
University of Virginia · US

Funding

A novel inflammation targeting Tc-99m probe for osteoarthritis imagingR21AR070987 · NIAMS · UNIVERSITY OF VIRGINIA · PI CUI, QUANJUN, PAN, DONGFENG · 2017 to 2018
$390k
NIAMS NIH HHS R21 AR070987
6 · The paper itself

Abstract

purpose/aim of the studyThe formyl peptide receptor (FPR) participates in the immune response, with roles in infection and inflammation. In this review article, we summarize the current literature on these roles before discussing the function of FPRs in the pathogenesis of musculoskeletal disorders including osteoarthritis (OA), degenerative disc disease (DDD), and rheumatoid arthritis (RA). Additionally, we discuss the potential diagnostic and therapeutic roles of FPRs in these domains.

methodsPubMed and Ovid MEDLINE searches were performed from 1965 through March 2022. Keywords included "FPR, tissue expression, inflammation, infection, musculoskeletal disorder, bone, rheumatoid arthritis, osteoarthritis, degenerative disc disease, mitochondria."

resultsSixty-nine studies were included in this review article. FPRs appear to be ubiquitous in the pathogenesis, diagnosis, and treatment of common musculoskeletal disorders. They can potentially be utilized for the earlier diagnosis of OA and DDD. They may be employed with mesenchymal stem cells (MSCs) to reverse OA and DDD pathologies. With anti-inflammatory, anti-osteolytic, and pro-angiogenic functions, they may broaden treatment options in RA.

conclusionsFPRs appear to be heavily involved in the pathogenesis of common musculoskeletal conditions, including arthritis, degenerative disc disease, and rheumatoid arthritis. Furthermore, they demonstrate much promise in the diagnosis and treatment of these conditions. Their roles should continue to be explored.

Indexed as

Arthritis, RheumatoidIntervertebral Disc DegenerationMusculoskeletal DiseasesOsteoarthritisHumansInflammationReceptors, Formyl PeptideReceptors, Formyl PeptideboneFormyl peptide receptorinfectioninflammationmusculoskeletal

Identifiers

PMID36440821
PMCPMC10164673
OpenAlexW4310177377

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.