Evidence map›Paper›PMID 36440644›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2023

Dentine biomodification by sulphonamides pre-treatment: bond strength, proteolytic inhibition, and antimicrobial activity.

Maristela Barbosa Portela, Caroliny Mello Barboza, Eduardo Moreira da Silva, Daniel Clemente de Moraes, Renata Antoun Simão, Clara Ribeiro de Souza, Verônica da Silva Cardoso, Antônio Ferreira-Pereira, Alane Beatriz Vermelho, Claudiu T Supuran

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Maristela Barbosa PortelaDepartamento de Odontotécnica, Laboratório Analítico de Biomateriais Restauradores (LABiom-R), Faculdade de Odontologia, Universidade Federal Fluminense, Niterói, Brazil.
Caroliny Mello BarbozaDepartamento de Odontotécnica, Laboratório Analítico de Biomateriais Restauradores (LABiom-R), Faculdade de Odontologia, Universidade Federal Fluminense, Niterói, Brazil.
Eduardo Moreira da SilvaDepartamento de Odontotécnica, Laboratório Analítico de Biomateriais Restauradores (LABiom-R), Faculdade de Odontologia, Universidade Federal Fluminense, Niterói, Brazil.
Daniel Clemente de MoraesLaboratório de Bioquímica Microbiana, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Renata Antoun SimãoInstituto Alberto Luiz Coimbra de Pós-Graduação e Pesquisa de Engenharia (COPPE), Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Clara Ribeiro de SouzaDepartamento de Odontotécnica, Laboratório Analítico de Biomateriais Restauradores (LABiom-R), Faculdade de Odontologia, Universidade Federal Fluminense, Niterói, Brazil.
Verônica da Silva CardosoBioinovar-Biotecnologia: Unidade de Biocatálise, Bioprodutos e Bioenergia (BIOINOVAR), Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Antônio Ferreira-PereiraLaboratório de Bioquímica Microbiana, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Alane Beatriz VermelhoBioinovar-Biotecnologia: Unidade de Biocatálise, Bioprodutos e Bioenergia (BIOINOVAR), Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.ORCID 0000-0001-5926-4172
Claudiu T SupuranNEUROFARBA Department, Sezione di Scienze Farmaceutiche, Universita degli Studi di Firenze, Florence, Italy.ORCID 0000-0003-4262-0323
Universidade Federal do Rio de Janeiro · BRUniversidade Federal Fluminense · BRIstituto Nazionale di Fisica Nucleare, Sezione di Firenze · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We evaluated the effects of dentine biomodification after pre-treatment with two sulphonamide carbonic anhydrase inhibitors (CAIs) of the N-[4-sulphamoylphenethylcarbamoyl]benzenesulphonamide type, investigating matrix metalloproteases activity, resin-dentine micro tensile bond strength, dentine surface wettability, and antimicrobial activities. Ninety-five sound-extracted human molars were selected for the study. Inhibitory effects were evaluated by gelatinase and collagenase activity tests and collagen degradation FT-IR spectroscopic analysis. Pre-treatment with the two CAIs kept the micro tensile values after 12 months of storage (32.23 ± 5.95) and cariogenic challenge (34.13 ± 2.71) similar to the initial, pre-treatment values (33.56 ± 4.34). A decreased

Indexed as

Anti-Infective AgentsDentinCollagenHumansSpectroscopy, Fourier Transform InfraredSulfonamidesAnti-Infective AgentsCollagenSulfonamidesantimicrobial activityCarbonic anhydrase inhibitordentinemetalloproteinasesStreptococcus mutans biofilm

Identifiers

PMID36440644
PMCPMC11392503
OpenAlexW4310203519

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.