Evidence map›Paper›PMID 36440595›Full record

ArticleVeterinary ophthalmology2023

Comparison of three rebound tonometers in normal and glaucomatous dogs.

Kimberly J Hodgson, Christine D Harman, Shayla Bajric, Ava Cabble, Amanda L Anderson, Hemalatha Palanivel, David A Taylor, András M Komáromy

Abstract readComparative Study
In one paragraph

Article in Veterinary ophthalmology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kimberly J HodgsonDepartment of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, USA.
Christine D HarmanDepartment of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, USA.
Shayla BajricDepartment of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, USA.
Ava CabbleDepartment of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, USA.
Amanda L AndersonDepartment of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, USA.
Hemalatha PalanivelReichert Technologies, New York, USA.
David A TaylorReichert Technologies, New York, USA.
András M KomáromyDepartment of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, USA.ORCID https://orcid.org/0000-0002-8845-0588

Funding

Therapy development for open-angle glaucomasR01EY025752 · NEI · MICHIGAN STATE UNIVERSITY · PI KOMAROMY, ANDRAS · 2017 to 2021
$3.2M
NEI NIH HHS R01 EY025752NEI NIH HHS R01-EY025752
6 · The paper itself

Abstract

objectiveThe objectives of the study were to compare intraocular pressure (IOP) readings across a wide range and obtained via three rebound tonometers in ADAMTS10-mutant Beagle-derived dogs with different stages of open-angle glaucoma (OAG) and normal control dogs and to investigate the effect of central corneal thickness (CCT). ANIMALS STUDIED: Measurements were performed on 99 eyes from 50 Beagle-derived dogs with variable genetics-16 non-glaucomatous and 34 with ADAMTS10-OAG. Seventeen OAG eyes were measured twice-with and without the use of IOP-lowering medications. PROCEDURES: IOP was measured in each eye using three tonometers with their "dog" setting-ICare® Tonovet (TV), ICare® Tonovet Plus® (TVP), and the novel Reichert® Tono-Vera® Vet (TVA)-in randomized order. CCT was measured with the Accutome® PachPen. Statistical analyses included one-way ANOVA, Tukey pairwise comparisons, and regression analyses of tonometer readings and pairwise IOP-CCT Pearson correlations (MiniTab®).

resultsA total of 116 IOP measurements were taken with each of the three tonometers. When comparing readings over a range of ~7-77 mmHg, mean IOPs from the TV were significantly lower compared with TVP (-4.6 mmHg, p < .001) and TVA (-3.7 mmHg, p = .001). We found no significant differences between TVA and TVP measurements (p = .695). There was a moderate positive correlation between CCT and IOP for TVA (r = 0.53, p < .001), TVP (r = 0.48, p < .001), and TV (r = 0.47, p < .001).

conclusionsOur data demonstrate strong agreement between TVP and TVA, suggesting that the TVA may similarly reflect true IOP values in canines. CCT influenced IOP measurements of all three tonometers.

Indexed as

Dog DiseasesGlaucomaGlaucoma, Open-AngleAnimalsDogsIntraocular PressureManometryReproducibility of ResultsTonometry, OcularADAMTS10caninecentral corneal thickness (CCT)glaucomaintraocular pressure (IOP)rebound tonometry

Identifiers

PMID36440595
PMCPMC10098477

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.