Evidence map›Paper›PMID 36440577›Full record

ArticleCirculation2023

Lipoprotein(a) in Youth and Prediction of Major Cardiovascular Outcomes in Adulthood.

Olli Raitakari, Noora Kartiosuo, Katja Pahkala, Nina Hutri-Kähönen, Lydia A Bazzano, Wei Chen, Elaine M Urbina, David R Jacobs, Alan Sinaiko, Julia Steinberger and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
15.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 76 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 9 institutions in 4 countries.

Olli RaitakariCentre for Population Health Research, University of Turku and Turku University Hospital, Finland (O.R., N.K., K.P.).ORCID 0000-0001-9365-3702
Noora KartiosuoCentre for Population Health Research, University of Turku and Turku University Hospital, Finland (O.R., N.K., K.P.).
Katja PahkalaCentre for Population Health Research, University of Turku and Turku University Hospital, Finland (O.R., N.K., K.P.).
Nina Hutri-KähönenTampere Centre for Skills Training and Simulation, Tampere University, Finland (N.H.-K.).
Lydia A BazzanoDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA (L.A.B., W.C.).ORCID 0000-0002-8958-1352
Wei ChenDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA (L.A.B., W.C.).ORCID 0000-0003-1566-7943
Elaine M UrbinaDepartment of Pediatrics, University of Cincinnati College of Medicine, OH (E.M.U., J.G.W.).ORCID 0000-0002-5640-6777
David R JacobsDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis (D.R.J.).ORCID 0000-0002-7232-0543
Alan SinaikoDepartment of Pediatrics, University of Minnesota Medical School, Minneapolis (A.S., J.S.).ORCID 0000-0001-8277-3493
Julia SteinbergerDepartment of Pediatrics, University of Minnesota Medical School, Minneapolis (A.S., J.S.).
Trudy BurnsDepartment of Medicine (M.J., J.V.), University of Turku, Finland.
Stephen R DanielsDepartment of Pediatrics, University of Colorado School of Medicine, Aurora (S.R.D.).
Alison VennMenzies Institute for Medical Research, University of Tasmania, Hobart, Australia (A.V., T.D.).ORCID 0000-0001-7090-1398
Jessica G WooDepartment of Pediatrics, University of Cincinnati College of Medicine, OH (E.M.U., J.G.W.).ORCID 0000-0003-3644-8432
Terry DwyerMenzies Institute for Medical Research, University of Tasmania, Hobart, Australia (A.V., T.D.).ORCID 0000-0002-2091-7663
Markus JuonalaDepartment of Medicine (M.J., J.V.), University of Turku, Finland.ORCID 0000-0001-9498-364X
Jorma ViikariDepartment of Medicine (M.J., J.V.), University of Turku, Finland.ORCID 0000-0001-6452-010X
University of Turku · FICincinnati Children's Hospital Medical Center · USTulane University · USUniversity of Minnesota Medical Center · USUniversity of Tasmania · AUChildren's Hospital Colorado · USTampere University · FIUniversity of Iowa · USUniversity of Minnesota · US

Funding

Childhood CV Risk and Adult CVD Outcomes: an International Long-term Follow-upR01HL121230 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI BURNS, TRUDY L, CHEN, WEI · 2015 to 2019
$13.3M
EVOLUTION OF CARDIOVASCULAR RISK WITH NORMAL AGINGR01AG016592 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI CHEN, WEI · 2000 to 2015
$11.7M
Lifespan Cardiovascular Risk Exposures and Alzheimer-related brain health: Bogalusa Heart StudyRF1AG041200 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI BAZZANO, LYDIA, CARMICHAEL, OWEN T. · 2019 to 2022
$4.2M
Supplemental Funding Request for RF1 AG062309 Early life glycemic status and Alzheimer's disease neuroimaging markers in middle age: the Bogalusa Heart StudyR01AG062309 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI BAZZANO, LYDIA, CARMICHAEL, OWEN T. · 2019 to 2023
$3.9M
A novel research infrastructure enabling life-course studies of healthy agingR33AG057983 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI BAZZANO, LYDIA · 2020 to 2022
$2.4M
Long-Term Burden of Maternal Cardiovascular Risk Factors and Birth OutcomesR01HD069587 · NICHD · TULANE UNIVERSITY OF LOUISIANA · PI HARVILLE, EMILY WHEELER · 2012 to 2015
$2.1M
Childhood Secondhand Smoke and Longitudinal Cardiovascular Risk ProfileR01ES021724 · NIEHS · TULANE UNIVERSITY OF LOUISIANA · PI CHEN, WEI · 2012 to 2014
$1.8M
Digital biomarkers of Alzheimers-related brain health and functionR21AG057983 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI BAZZANO, LYDIA, URBINA, ELAINE MOTT · 2018 to 2020
$812k
Childhood Growth, Biological Aging and Midlife Cardio-Metabolic OutcomesR03AG060619 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI CHEN, WEI · 2018 to 2019
$151k
Path Analysis of Metabolic Syndrome in YouthR03HD047247 · NICHD · TULANE UNIVERSITY OF LOUISIANA · PI CHEN, WEI · 2004 to 2005
$149k
Birth Weight, Postnatal Growth, Blood Pressure and Subclinical Cardiovascular DisR03HD062783 · NICHD · TULANE UNIVERSITY OF LOUISIANA · PI CHEN, WEI · 2010 to 2011
$146k
PROTEOGLYCANS IN THE PATHOGENESIS OF ATHEROSCLEROSISR01HL002942 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI BERENSON, GERALD S · 1985 to 1992
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NHLBI NIH HHS P50 HL015103NHLBI NIH HHS R01 HL002942NHLBI NIH HHS R01 HL121230NIA NIH HHS R01 AG016592NIA NIH HHS R01 AG062309NIA NIH HHS R03 AG060619NIA NIH HHS R21 AG057983NIA NIH HHS R33 AG057983NIA NIH HHS RF1 AG041200NICHD NIH HHS R01 HD032194NICHD NIH HHS R01 HD069587NICHD NIH HHS R03 HD047247NICHD NIH HHS R03 HD062783NIEHS NIH HHS R01 ES021724
6 · The paper itself

Abstract

backgroundElevated lipoprotein(a) [Lp(a)] is a common risk factor for cardiovascular disease outcomes with unknown mechanisms. We examined its potential role in identifying youths who are at increased risk of developing adult atherosclerotic cardiovascular disease (ASCVD).

methodsLp(a) levels measured in youth 9 to 24 years of age were linked to adult ASCVD and carotid intima-media thickness in the YFS (Cardiovascular Risk in Young Finns Study), in which 95 of the original 3596 participants (2.7%) recruited as children have been diagnosed with ASCVD at a median of 47 years of age. Results observed in YFS were replicated with the use of data for White participants from the BHS (Bogalusa Heart Study). In BHS, 587 White individuals had data on youth Lp(a) (measured at 8-17 years of age) and information on adult events, including 15 cases and 572 noncases. Analyses were performed with the use of Cox proportional hazard regression.

resultsIn YFS, those who had been exposed to high Lp(a) level in youth [defined as Lp(a) ≥30 mg/dL] had ≈2 times greater risk of developing adult ASCVD compared with nonexposed individuals (hazard ratio, 2.0 [95% CI, 1.4-2.6]). Youth risk factors, including Lp(a), low-density lipoprotein cholesterol, body mass index, and smoking, were all independently associated with higher risk. In BHS, in an age- and sex-adjusted model, White individuals who had been exposed to high Lp(a) had 2.5 times greater risk (95% CI, 0.9-6.8) of developing adult ASCVD compared with nonexposed individuals. When also adjusted for low-density lipoprotein cholesterol and body mass index, the risk associated with high Lp(a) remained unchanged (hazard ratio, 2.4 [95% CI, 0.8-7.3]). In a multivariable model for pooled data, individuals exposed to high Lp(a) had 2.0 times greater risk (95% CI, 1.0-3.7) of developing adult ASCVD compared with nonexposed individuals. No association was detected between youth Lp(a) and adult carotid artery thickness in either cohort or pooled data.

conclusionsElevated Lp(a) level identified in youth is a risk factor for adult atherosclerotic cardiovascular outcomes but not for increased carotid intima-media thickness.

Indexed as

AtherosclerosisCardiovascular DiseasesAdolescentAdultCarotid Intima-Media ThicknessChildCholesterol, LDLHumansLipoprotein(a)Risk AssessmentRisk FactorsCholesterol, LDLLipoprotein(a)atherosclerosisepidemiologylipoproteinslongitudinal studiesrisk assessmentrisk factors

Identifiers

PMID36440577
PMCPMC9797445
OpenAlexW4310212422

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.