ArticleFrontiers in psychiatry2022
A genetic association study reveals the relationship between the oral microbiome and anxiety and depression symptoms.
Article in Frontiers in psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Interplay of depressive symptoms and clinical oral health conditions: a systematic review and meta-analysis.Brazilian oral research · 2026Pooled it
- Optimization of potential targets for antidepressant Chinese medicines: AI and multi-omics methods.Chinese medicine · 2026Review
- A community screening tool for neuropsychiatric symptoms in the elderly: integrating cortisol, microbiome, and social factors with machine learning.Translational psychiatry · 2026Observational
- Oral Dysbiosis and Neuroinflammation: Implications for Alzheimer's, Parkinson's and Mood Disorders.Microorganisms · 2026Review
- Linking oral microbiome with mental health: A review.Bioinformation · 2026Article
- Alterations in Neuroinflammation, Microglia and Neuroplasticity in the Rat Hippocampus in a Combined Model of Periodontitis and Depression.CNS neuroscience & therapeutics · 2025Article
- From gums to moods: Exploring the impact of the oral microbiota on depression.Brain, behavior, & immunity - health · 2025Review
- Trace Amine-associated Receptors (TAARs): Candidate Targets in the Treatment of Bipolar Disorders.Actas espanolas de psiquiatria · 2025Review
- Exploring the Role of Oral Microbiota in the Pathophysiology and Treatment of Bruxism.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Review
- Unveiling the Relationship Between Oral Microbiota and Alzheimer's Disease: A Genetic Instrumental Variable Analysis via Mendelian Randomization.Brain and behavior · 2025Article
- Association Between Oral Dysbiosis and Depression: A Systematic Review.Journal of clinical medicine · 2025Review
- Modulating oral microbiota ameliorates hypobaric hypoxia-induced anxiety- and depression-like behaviors in mice.World journal of psychiatry · 2025Article
- Relationship between depression and oral microbiome diversity: analysis of NHANES data (2009-2012).BMC oral health · 2025Article
- Oral microbiota and central nervous system diseases: A review.Neuroprotection (Chichester, England) · 2025Review
- TAAR9 knockout increases hippocampal serotonin and alters grooming behavior in rats.Frontiers in pharmacology · 2025Article
- Human oral microbiome and its influence on mental health and brain disorders.AIMS microbiology · 2025Review
- Stress and mental health symptoms in early pregnancy are associated with the oral microbiome.BMJ mental health · 2024Article
- Probing the oral-brain connection: oral microbiome patterns in a large community cohort with anxiety, depression, and trauma symptoms, and periodontal outcomes.Translational psychiatry · 2024Article
- Article
- Balancing the Oral-Gut-Brain Axis with Diet.Nutrients · 2024Review
Corrections and comments
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Growing evidence supports that alterations in the gut microbiota play an essential role in the etiology of anxiety, depression, and other psychiatric disorders. However, the potential effect of oral microbiota on mental health has received little attention. Methods: Using the latest genome-wide association study (GWAS) summary data of the oral microbiome, polygenic risk scores (PRSs) of 285 salivary microbiomes and 309 tongue dorsum microbiomes were conducted. Logistic and linear regression models were applied to evaluate the relationship between salivary-tongue dorsum microbiome interactions with anxiety and depression. Two-sample Mendelian randomization (MR) was utilized to compute the causal effects between the oral microbiome, anxiety, and depression. Results: We observed significant salivary-tongue dorsum microbiome interactions related to anxiety and depression traits. Significantly, one common interaction was observed to be associated with both anxiety score and depression score, Conclusion: This study systematically explored the relationship between the oral microbiome and anxiety and depression, which could help improve our understanding of disease pathogenesis and propose new diagnostic targets and early intervention strategies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.