Evidence map›Paper›PMID 36439959›Full record

ArticleSaudi journal of biological sciences2023

Evaluation of testicular torsion management in Ogbomoso, South-Western Nigeria and surgical detorsion-augmented treatment with phytochemical fractions of

Oladele Ayobami Afolabi, Babatunde Adebola Alabi, Richard Adedamola Ajike, Olubunmi Simeon Oyekunle, Wakeel Adegoke, Abodunrin Adebayo Ojetola

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Saudi journal of biological sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Oladele Ayobami AfolabiDepartment of Physiology, Faculty of Basic Medical Science, Ladoke Akintola University of Technology, Ogbomoso, Nigeria.
Babatunde Adebola AlabiDepartment of Pharmacology & Therapeutics, Faculty of Basic Clinical Sciences, Bowen University, Iwo, Nigeria.
Richard Adedamola AjikeDepartment of Physiology, Faculty of Basic Medical Science, Ladoke Akintola University of Technology, Ogbomoso, Nigeria.
Olubunmi Simeon OyekunleDepartment of Physiology, Faculty of Basic Medical Science, Ladoke Akintola University of Technology, Ogbomoso, Nigeria.
Wakeel AdegokeDepartment of Pharmacology & Therapeutics, Faculty of Basic Medical Sciences, University of Ibadan, Ibadan, Nigeria.
Abodunrin Adebayo OjetolaDepartment of Physiology, Faculty of Basic Medical Science, Redeemer's University, Ede, Nigeria.
Ladoke Akintola University of Technology · NGBowen University · NGRedeemer's University · NGUniversity of Ibadan · NG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: There is need to investigate whether phytochemicals along with surgical detorsion could serve as better managements options in TT patients rather than surgical detorsion (SD) alone. Methods: The descriptive cross-sectional part of this study is questionnaire-based addressing sociodemographic characteristics of participants and their experience in management of TT. In the experimental part, male rats (n = 32) were grouped into: sham, Ischemia-reperfusion injury (IRI), dichloromethane (DCM) and ethanol fraction (100 mg/kg) of CO. Evaluation of tissue GPx, total thiol, SOD, MDA and H Results: 68.9 % respondents agreed that SD alone is non-effective in the management of TT while 83.6 % reported a need to augment surgery with medications. Oxidative stress markers like H Conclusions: Quantitative cross-sectional study has revealed through experience of clinicians that surgical detorsion alone is not effective in managing TT. Augmented treatment with CO leaf fractions suppressed testicular IRI through inhibition of pro-apoptotic proteins expression, oxidative stress and inflammation.

Indexed as

2-isopropylethylamineABP, Androgen binding proteinApoptosisCO, Corchorus olitoriousCross-sectional studyDCM, DichloromethaneETC, Electron transport chainGC-MS, Gas chromatography-mass spectroscopyGpx, Glutathione peroxidaseGSH, Reduced glutathioneGST, Glutathione-S-TransfeaseH2O2, Hydrogen peroxideIL-6, Interleukine 6ImmunohistochemistryInflammationIRI, Ischemia reperfusion injuryMass spectroscopyMDA, MalondialdehydeMPO, MyeloperoxidaseNSAID, Non-steroidal anti-inflammatory drugOxidative stressPCT, PercentageROS, Reactive oxygen speciesSD, Surgical detorsionSOD, Superoxide dismutaseTNF- α, Tumor necrotic factor- αTTDT, Testicular torsion/detorsion

Identifiers

PMID36439959
PMCPMC9694087
OpenAlexW4309103096

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.