Evidence map›Paper›PMID 36439642›Full record

ArticleCurrent research in food science2022

Nutritional supplements formulated to prevent cognitive impairment in animals.

Mengyu Cai, Yicui Qu, Zifu Ren, Xin Xu, Chuyang Ye, Hongtao Lu, Yinyin Zhang, Wenlan Pan, Hui Shen, Hongxia Li

Open access · goldAbstract read

In one paragraph

Article in Current research in food science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.1field-weighted citation impact, top 56% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

Vaginal-Derived Potential Probiotics and Their Postbiotics Alleviate Aerobic Vaginitis via Suppressing TLR4/MyD88/NF-κB Signalling Pathway and Potentially Enhancing Vaginal Barrier.Microbial biotechnology · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mengyu CaiDepartment of Nutrition and Food Hygiene, Faculty of Naval Medicine, Naval Medical University, 200433, Shanghai, China.

Yicui QuDepartment of Nutrition and Food Hygiene, Faculty of Naval Medicine, Naval Medical University, 200433, Shanghai, China.

Zifu RenDepartment of Nutrition and Food Hygiene, Faculty of Naval Medicine, Naval Medical University, 200433, Shanghai, China.

Xin XuDepartment of Nutrition and Food Hygiene, Faculty of Naval Medicine, Naval Medical University, 200433, Shanghai, China.

Chuyang YeDepartment of Nutrition and Food Hygiene, Faculty of Naval Medicine, Naval Medical University, 200433, Shanghai, China.

Hongtao LuDepartment of Nutrition and Food Hygiene, Faculty of Naval Medicine, Naval Medical University, 200433, Shanghai, China.

Yinyin ZhangDepartment of Nutrition and Food Hygiene, Faculty of Naval Medicine, Naval Medical University, 200433, Shanghai, China.

Wenlan PanDepartment of Nutrition and Food Hygiene, Faculty of Naval Medicine, Naval Medical University, 200433, Shanghai, China.

Hui ShenDepartment of Nutrition and Food Hygiene, Faculty of Naval Medicine, Naval Medical University, 200433, Shanghai, China.

Hongxia LiDepartment of Nutrition and Food Hygiene, Faculty of Naval Medicine, Naval Medical University, 200433, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heat stress will cause a series of response in the living system and the most significant impact is on brain functions. The aim of this article is to develop nutritional supplements that can alleviate cognitive decline caused by heat stress. In this article, we screen functional food factors which can prevent or relieve effects on heat stress injury based on bioinformatics. 129 function factors related to the crossover targets were obtained, and a food database related to the prevention of high-temperature impairment was constructed. After a series of scoring standards combined with food classification, two formulas-nutrition fortifier formula (tyrosine and multivitamin B) and plant compound formula (quercetin, proanthocyanidin, and naringin) were investigated using animal experiments to determine their ability to prevent cognitive impairment of heat-stressed animals. Our results demonstrated that certain functional food factors and our two designed formulations significantly prevent cognitive impairment of heat-stressed animals. Further mechanism was carried out by cell viability assay, reactive oxygen species assay, real-time quantitative PCR and Western blot. The results showed that the plant compound formula diluted 4000 times had the best relieving effect on HT22 after heat stress, and this concentration formula can significantly alleviate the elevated levels of reactive oxygen species caused by heat stress. This formula also can significantly down-regulate IL-1β, IL-6, TNF-α, IL-10, iNOS and COX-2 expression. Likewise, Western blot results showed that the formula could activate the cAMP pathway and increase the expression of phosphorylated PKA and BDNF in hippocampal cells.

Indexed as

BioinformaticsFood functional factorsHeat stressNutritional supplements

Identifiers

PMID36439642

DOI10.1016/j.crfs.2022.11.004

PMCPMC9691433

OpenAlexW4309380040

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.