ArticleJournal of orthopaedic translation2023
Combination of cobalt, chromium and titanium nanoparticles increases cytotoxicity
Article in Journal of orthopaedic translation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Beyond Biocompatibility: Immune Dysregulation, Oxidative Stress, and Tissue Intolerance Associated with Ti-6Al-4V Dental Implants-A Critical Review and Perspective.Antioxidants (Basel, Switzerland) · 2026Review
- Selenium nanoparticles alleviate cobalt toxicity in artificial joint metal prostheses by inhibiting ferroptosis through activation of the PRDX6/GPX4 pathway.Materials today. Bio · 2025Article
- The Association of Blood Cobalt Levels with Cardiovascular and Chronic Kidney Diseases: Mediating Role of Inflammatory Indicators (SII, NLR, PLR, NMLR, and LMR).Cardiovascular toxicology · 2025Article
- Multiscale metal-based nanocomposites for bone and joint disease therapies.Materials today. Bio · 2025Review
- CLINICALLY RELEVANT METALLIC NANOPARTICLES IN TUBERCULOSIS DIAGNOSIS AND THERAPY.Advanced therapeutics · 2025Article
- Evaluation of Titanium Particles, TNF-α, and Caspase-3 Concentrations in Patients with Bones Fixations of the Maxilla and Mandibule.International journal of molecular sciences · 2025Article
- Evaluation of bacterial adherence and biofilm development on an anodized stainless-steel surface for the prevention of osteosynthesis-associated infections.Journal of bone and joint infection · 2025Article
- Magnesium as an emerging bioactive material for orthopedic applications: bedside needs lead the way from innovation to clinical translation.Regenerative biomaterials · 2025Review
- Article
- In vivo assessment of TiOAnalytical and bioanalytical chemistry · 2024Article
- Interaction pathways of implant metal localized corrosion and macrophage inflammatory reactions.Bioactive materials · 2024Article
- Regulation of Osteoimmune Microenvironment and Osteogenesis by 3D-Printed PLAG/black Phosphorus Scaffolds for Bone Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Corrosion Products from Metallic Implants Induce ROS and Cell Death in Human MotoneuronsJournal of functional biomaterials · 2023Article
- 2023 January issue Journal of Orthopaedic Translation.Journal of orthopaedic translation · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 8 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The mixture of different metallic nanoparticles released from intended and unintended wearing of orthopaedic implants such as the Co/Cr cup and head, Co/Cr sleeves or tapers and their interface with Ti stems in the case of hip prostheses are a leading cause of adverse inflammatory responses and cytotoxicity to the host. Methods: This study assessed the Results: The results demonstrated that Co, Cr, and Ti nanoparticles and their combination were phagocytosed by macrophages both Conclusion: This study demonstrated that the combination of Co/Cr/Ti nanoparticles was more cytotoxic than any of the individual metals Translational potential of this article: This study highlights the importance of preclinical assessments of potential nanoparticles produced by wear and tear of metal implants using macrophages and animal models, in particular their combinational toxicity in addition to the assessments of the bulk metallic materials.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.