ArticleFrontiers in veterinary science2022
RELSA-A multidimensional procedure for the comparative assessment of well-being and the quantitative determination of severity in experimental procedures.
Article in Frontiers in veterinary science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Activity as a readout parameter for neurobehavioral research and severity assessment in laboratory rodents: a systematic comparison and meta-analysis of measurement techniques.Scientific reports · 2026Pooled it
- Voluntary Wheel Running as Refinement Tool for Postoperative Severity Assessment and Humane Endpoint Detection in Rats with Brain Tumors.Brain sciences · 2026Article
- Comparative analysis of dose-response variability and severity in STZ-induced diabetes: female vs. male NSG mice.Scientific reports · 2026Article
- One size does not fit all: Guidelines for designing a score sheet for animal experiments - eight essential steps.Laboratory animals · 2026Article
- Beyond single metrics: Multi-parameter home-cage monitoring improves welfare assessment.Laboratory animals · 2026Article
- Refining humane endpoint detection by time-series forecasting and threshold definition using a multivariate severity score.Frontiers in physiology · 2026Article
- Corridor-based relative severity assessment of the canine anaesthetic course.Frontiers in veterinary science · 2026Article
- A scoping review of ethical decisions and decision tools for experimental animal protocols.BMC medical ethics · 2025Article
- Improving pain management for murine orthotopic xenograft models of acute lymphoblastic leukemia.Lab animal · 2025Article
- Video based heart rate detection in unrestrained laboratory rats: a feasibility analysis.Scientific reports · 2025Article
- Advocating for automation in animal research: using home cage monitoring to advance welfare, reproducibility and scientific openness.Disease models & mechanisms · 2025Article
- Burrowing Behavior as Robust Parameter for Early Humane Endpoint Determination in Murine Models for Pancreatic Cancer.Animals : an open access journal from MDPI · 2025Article
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- Exploring dose-response variability and relative severity assessment in STZ-induced diabetes male NSG mice.Scientific reports · 2024Article
- Evidence-Based Severity Assessment of Animal Models for Pancreatic Cancer.Biomedicines · 2024Article
- Continuous monitoring of physiological data using the patient vital status fusion score in septic critical care patients.Scientific reports · 2024Article
- Refining Stereotaxic Neurosurgery Techniques and Welfare Assessment for Long-Term Intracerebroventricular Device Implantation in Rodents.Animals : an open access journal from MDPI · 2023Article
- Robustness of a multivariate composite score when evaluating distress of animal models for gastrointestinal diseases.Scientific reports · 2023Article
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Authors and funding
11 authors.
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Abstract
Good science in translational research requires good animal welfare according to the principles of 3Rs. In many countries, determining animal welfare is a mandatory legal requirement, implying a categorization of animal suffering, traditionally dominated by subjective scorings. However, how such methods can be objectified and refined to compare impairments between animals, subgroups, and animal models remained unclear. Therefore, we developed the RELative Severity Assessment (RELSA) procedure to establish an evidence-based method based on quantitative outcome measures such as body weight, burrowing behavior, heart rate, heart rate variability, temperature, and activity to obtain a relative metric for severity comparisons. The RELSA procedure provided the necessary framework to get severity gradings in TM-implanted mice, yielding four distinct RELSA thresholds L1<0.27, L2<0.59, L3<0.79, and L4<3.45. We show further that severity patterns in the contributing variables are time and model-specific and use this information to obtain contextualized
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