Evidence map›Paper›PMID 36439243›Full record

ArticleFrontiers in physiology2022

Streamlined single-molecule RNA-FISH of core clock mRNAs in clock neurons in whole mount

Ye Yuan, Marc-Antonio Padilla, Dunham Clark, Swathi Yadlapalli

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. An intron-based timer for circadian rhythms.bioRxiv : the preprint server for biology · 2025
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ye YuanCellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI, United States.
Marc-Antonio PadillaNeuroscience Graduate Program, University of Michigan, Ann Arbor, MI, United States.
Dunham ClarkCell and Developmental Biology Department, University of Michigan, Ann Arbor, MI, United States.
Swathi YadlapalliCellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI, United States.
University of Michigan–Ann Arbor · US

Funding

Early Stage Training in the NeurosciencesT32NS076401 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Carol Fuzeti Elias, LESLIE S. SATIN · 2011 to 2026
$3.1M
NINDS NIH HHS T32 NS076401
6 · The paper itself

Abstract

Circadian clocks are ∼24-h timekeepers that control rhythms in almost all aspects of our behavior and physiology. While it is well known that subcellular localization of core clock proteins plays a critical role in circadian regulation, very little is known about the spatiotemporal organization of core clock mRNAs and its role in generating ∼24-h circadian rhythms. Here we describe a streamlined single molecule Fluorescence

Indexed as

circadian rhythmsDrosophila clock neuronsmachine learning-based analysis pipelinesingle molecule RNA-fluorescence in situ hybridization (smFISH)spatiotemporal organization of clock mRNAs

Identifiers

PMID36439243
PMCPMC9682093
OpenAlexW4308726185

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.