Evidence map›Paper›PMID 36439106›Full record

ReviewFrontiers in immunology2022

Remodeling tumor microenvironment with natural products to overcome drug resistance.

Wanlu Zhang, Shubo Li, Chunting Li, Tianye Li, Yongye Huang

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

  1. Pooled it
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  7. In Vitro Antineoplastic Effects ofFood science & nutrition · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Wanlu ZhangCollege of Life and Health Sciences, Northeastern University, Shenyang, China.
Shubo LiLiaoning Center for Animal Disease Control and Prevention, Liaoning Agricultural Development Service Center, Shenyang, China.
Chunting LiCollege of Life and Health Sciences, Northeastern University, Shenyang, China.
Tianye LiCollege of Life and Health Sciences, Northeastern University, Shenyang, China.
Yongye HuangCollege of Life and Health Sciences, Northeastern University, Shenyang, China.
Northeastern University · CNShenyang Center for Disease Control and Prevention · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With cancer incidence rates continuing to increase and occurrence of resistance in drug treatment, there is a pressing demand to find safer and more effective anticancer strategy for cancer patients. Natural products, have the advantage of low toxicity and multiple action targets, are always used in the treatment of cancer prevention in early stage and cancer supplement in late stage. Tumor microenvironment is necessary for cancer cells to survive and progression, and immune activation is a vital means for the tumor microenvironment to eliminate cancer cells. A number of studies have found that various natural products could target and regulate immune cells such as T cells, macrophages, mast cells as well as inflammatory cytokines in the tumor microenvironment. Natural products tuning the tumor microenvironment

Indexed as

Biological ProductsNeoplasmsDrug ResistanceHumansImmunotherapyTumor MicroenvironmentBiological Productscancer stem cellsdrug resistancenatural productsp53traditional Chinese medicinetumor microenvironment

Identifiers

PMID36439106
PMCPMC9685561
OpenAlexW4308868748

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.