ArticleBioactive materials2023
A biomimetic gradient porous cage with a micro-structure for enhancing mechanical properties and accelerating osseointegration in spinal fusion.
Article in Bioactive materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- Measurement and evaluation of surgical models of spinal fusion in mice, rats, and rabbits.Animal models and experimental medicine · 2026Article
- Integrating Structures and Biology: Cellular and Molecular Interactions with Functionally Graded Spinal Cage Designs.International journal of molecular sciences · 2026Review
- Modular assembly of nanocomposite hydrogel with NIR-responsive black phosphorus release and mild photothermal synergy for enhanced regenerative microenvironment and accelerated infectious bone repair.Journal of nanobiotechnology · 2026Article
- Structural design and biomechanical analysis of anti- subsidence gradient porous artificial vertebrae combined with a topology framework.BMC musculoskeletal disorders · 2026Article
- Innovative 3D-printed porous piezoelectric poly(vinylidene fluoride) cages with accelerated spinal fusion.Materials today. Bio · 2025Article
- Transforming spinal surgery with innovations in biologics and additive manufacturing.Materials today. Bio · 2025Review
- Innovative 3D-printed porous tantalum cage with non-window design to accelerate spinal fusion: A proof-of-concept study.Materials today. Bio · 2025Article
- Structural design and biomechanical analysis of a combined titanium and polyetheretherketone cage based on PE-PLIF fusion.Medical & biological engineering & computing · 2025Article
- Evaluation of biological performance of 3D printed trabecular porous tantalum spine fusion cage in large animal models.Journal of orthopaedic translation · 2025Article
- Progress in the Application of Porous Tantalum Metal in Hip Joint Surgery.Orthopaedic surgery · 2024Review
- A novel porous interbody fusion cage modified by microarc oxidation and hydrothermal treatment technology accelerate osseointegration and spinal fusion in sheep.RSC advances · 2024Article
- High Strength and Shape Memory Spinal Fusion Device for Minimally Invasive Interbody Fusions.International journal of nanomedicine · 2024Article
- A novel artificial vertebral implant with Gyroid porous structures for reducing the subsidence and mechanical failure rate after vertebral body replacement.Journal of orthopaedic surgery and research · 2023Article
- 3D printing metal implants in orthopedic surgery: Methods, applications and future prospects.Journal of orthopaedic translation · 2023Review
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: Spinal fusion is a widely employed treatment of patients with degenerative disc disease, in which a cage is used to replace the disc for spinal fusion. But it often fails for insufficient mechanical strength and poor osseointegration. Here, we designed a polyether-ether-ketone (PEEK)/tantalum (Ta) composite cage with a biomimetic gradient porous micro-structure, simultaneously enhancing mechanical properties and accelerating osseointegration in spinal fusion. Materials and methods: In the study, based on the mechanical performances of PEEK and osteogenic potential of Ta, and the three-dimensional (3D) structures of cuttlebone and vertebra, the cages were respectively 3D printed by pure PEEK, PEEK with 5 wt% Ta (PEEK/Ta-5), PEEK with 10 wt% Ta (PEEK/Ta-10) and PEEK with 15 wt% Ta (PEEK/Ta-15), then verified Results: Vertebral Gyroid structure PEEK/Ta-15 cage exhibited superior mechanical properties than Cuttlebone-like structure PEEK/Ta-15 cage, closer to the cervical vertebra. Furthermore, PEEK/Ta-15 cage with higher Ta microparticles in PEEK provided a biomimetic gradient porous micro-structure with higher surface energy, guiding cell biological behavior, promoting new bone penetration, and accelerating osseointegration Conclusion: In conclusion, the study designed a biomimetic gradient porous cage with a micro-structure for enhancing mechanical properties, accelerating osseointegration and forming an anatomical lock in the fusion segment through composites, mechanical efficiency, surface extension, and pores.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.