Evidence map›Paper›PMID 36439047›Full record

ArticleHealth science reports2022

Iron stores in steady-state sickle cell disease children accessing care at a sickle cell disease clinic in Kumasi, Ghana: A cross-sectional study.

Ernest Amanor, Alexander Kwarteng, Amma Larbi, Fatima Amponsah Fordjour, Kelvin Kwaku Koranteng, David Sebbie Sackey, Emmanuel Bannor, Francis Adjei Osei, Aliyu Mohammed, Ezekiel Bonwin Ackah and 4 more

Open access · goldAbstract read
In one paragraph

Article in Health science reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Ernest AmanorDepartment of Biochemistry and Biotechnology, College of Science Kwame Nkrumah University of Science and Technology Kumasi Ghana.ORCID 0000-0002-2416-163X
Alexander KwartengDepartment of Biochemistry and Biotechnology, College of Science Kwame Nkrumah University of Science and Technology Kumasi Ghana.
Amma LarbiDepartment of Biochemistry and Biotechnology, College of Science Kwame Nkrumah University of Science and Technology Kumasi Ghana.
Fatima Amponsah FordjourDepartment of Biochemistry and Biotechnology, College of Science Kwame Nkrumah University of Science and Technology Kumasi Ghana.ORCID 0000-0002-8046-5099
Kelvin Kwaku KorantengDepartment of Biochemistry and Biotechnology, College of Science Kwame Nkrumah University of Science and Technology Kumasi Ghana.
David Sebbie SackeyDepartment of Hematology, Laboratory Services Directorate Komfo Anokye Teaching Hospital Kumasi Ghana.
Emmanuel BannorDepartment of Hematology, Laboratory Services Directorate Komfo Anokye Teaching Hospital Kumasi Ghana.
Francis Adjei OseiDepartment of International Health, School of Public Health Kwame Nkrumah University of Science and Technology Kumasi Ghana.
Aliyu MohammedDepartment of Biostatistics and Epidemiology, School of Public Health Kwame Nkrumah University of Science and Technology Kumasi Ghana.
Ezekiel Bonwin AckahDepartment of Medical Diagnostics, School of Public Health Kwame Nkrumah University of Science and Technology Kumasi Ghana.
Samuel Frimpong OdoomChild Health Directorate Komfo Anokye Teaching Hospital Kumasi Ghana.ORCID 0000-0001-8398-3898
Samuel Blay NguahChild Health Directorate Komfo Anokye Teaching Hospital Kumasi Ghana.
Vivian PaintsilChild Health Directorate Komfo Anokye Teaching Hospital Kumasi Ghana.
Alex Osei-AkotoChild Health Directorate Komfo Anokye Teaching Hospital Kumasi Ghana.
Kwame Nkrumah University of Science and Technology · GHKomfo Anokye Teaching Hospital · GH

Funding

The Sickle Pan-African Research Consortium (SPARCO)U24HL135881 · NHLBI · MUHIMBILI UNIVERSITY/ ALLIED HLTH SCIS · PI MAKANI, JULIE · 2017 to 2025
$5.3M
Ghana-SPARCO: Ghana Sickle Pan-African Research ConsortiumU01HL157004 · NHLBI · KWAME NKRUMAH UNIVERSITY/SCIENCE/TECH · PI OFORI-ACQUAH, SOLOMON FIIFI, SARFO, FRED STEPHEN · 2021 to 2025
$1.4M
NHLBI NIH HHS U01 HL157004NHLBI NIH HHS U24 HL135881
6 · The paper itself

Abstract

Background and Aims: Children with sickle cell disease (SCD) have an increased risk of multiple hemotransfusions and this can predispose them to elevated iron stores. The objectives of the study were to determine the extent of elevated iron stores and the associated risk factors in a population of steady-state SCD children in Ghana. Methods: This cross-sectional study was conducted at the pediatric sickle cell clinic at the Komfo Anokye Teaching Hospital. Complete blood count and serum ferritin assay were performed for ( Results: The mean (standard deviation) age of the participants was 9.61 (±4.34) years, and 51% of them were males. About 17% of SCD children had elevated iron stores and receiving at least three hemotransfusions during the last 12 months was strongly associated with elevated iron stores ( Conclusion: The magnitude of elevated iron stores was high among children with SCD in steady-state. Red cell indices could provide invaluable information regarding the risk of elevated iron stores. SCD children who have a history of chronic hemotransfusion or had received at least three hemotransfusions in a year should be monitored for elevated iron stores.

Indexed as

complete blood counthemotransfusioniron storesred cell indicesserum ferritinsickle cell disease

Identifiers

PMID36439047
PMCPMC9686355
OpenAlexW4310022405

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.