Evidence map›Paper›PMID 36438612›Full record

ArticleAdvances in hematology2022

Association of Pulmonary Hypertension and Monoclonal Gammopathy of Undetermined Significance.

Melissa A Lyle, Subir Bhatia, Eric Fenstad, Darrell Schroeder, Robert B McCully, Martha Q Lacy, Wayne Feyereisn

Abstract read
In one paragraph

Article in Advances in hematology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. A Comprehensive Review of Monoclonal Gammopathy of Undetermined Significance.Journal of the advanced practitioner in oncology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Melissa A LyleDivision of Advanced Heart Failure and Transplantation, Mayo Clinic, Jacksonville, FL, USA.ORCID https://orcid.org/0000-0002-5671-5596
Subir BhatiaDepartment of Cardiology, Harbor UCLA Medical Center, Torrance, CA, USA.ORCID https://orcid.org/0000-0002-7174-1530
Eric FenstadDepartment of Cardiovascular, Medicine Ascentia Health, Brainerd, MN, USA.ORCID https://orcid.org/0000-0003-1440-1174
Darrell SchroederDepartment of Quantitative Health Science, Mayo Clinic, Rochester, Minnesota, USA.ORCID https://orcid.org/0000-0001-8591-5936
Robert B McCullyDepartment of Cardiology, Mayo Clinic, Rochester, MN, USA.ORCID https://orcid.org/0000-0003-2768-4652
Martha Q LacyDepartment of Hematology, Mayo Clinic, Rochester, Minnesota, USA.ORCID https://orcid.org/0000-0003-1193-1559
Wayne FeyereisnDepartment of Medicine, Mayo Clinic, Rochester, Minnesota, USA.ORCID https://orcid.org/0000-0003-0163-6249

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To determine the prevalence of monoclonal gammopathy of undetermined significance (MGUS) in patients with PH as well as precapillary PH. Methods: Olmsted County residents with PH, diagnosed between 1/1/1995 and 9/30/2017, were identified, and age and sex were matched to a normal control group. The PH group and normal control group were then cross-referenced with the Mayo Clinic MGUS database. Charts were reviewed to verify MGUS and PH. Heart catheterization data were then analyzed in these patients for reference to the gold standard for diagnosis. Results: There were 3419 patients diagnosed with PH by echocardiography between 1995 and 2017 in Olmsted County that met the criteria of our study. When the PH group ( Conclusions: There is a higher prevalence of MGUS in patients with PH and precapillary PH compared with normal controls. This association cannot be explained fully by other underlying diagnoses associated with PH. Assessing for this in patients with PH of unclear etiology may be reasonable in the workup of patients found to have PH.

Identifiers

PMID36438612
PMCPMC9699780

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