Evidence map›Paper›PMID 36438482›Full record

ArticleTheranostics2022

The PROTAC selectively degrading Bcl-x

Shaoqing Zhang, Yue Chen, Zhongli Xu, Jun Yang, Renhong Sun, Juan Wang, Yiming Sun, Biao Jiang, Xiaobao Yang, Wenfu Tan

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Shaoqing ZhangDepartment of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, P.R. China.
Yue ChenDepartment of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, P.R. China.
Zhongli XuShanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai 201210, P.R. China.
Jun YangDepartment of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, P.R. China.
Renhong SunGluetacs Therapeutics (Shanghai) Co., Ltd., No. 99 Haike Road, Zhangjiang Hi-Tech Park, Shanghai, 201210, P. R. China.
Juan WangDepartment of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, P.R. China.
Yiming SunDivision of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, P. R. China.
Biao JiangShanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai 201210, P.R. China.
Xiaobao YangShanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai 201210, P.R. China.
Wenfu TanDepartment of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, P.R. China.
Fudan University · CNShanghaiTech University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antineoplastic AgentsNeoplasmsAnimalsBone DevelopmentChildHedgehog ProteinsHumansMicePositron Emission Tomography Computed TomographyProteolysisProto-Oncogene Proteins c-bcl-2Ubiquitin-Protein LigasesZinc Finger Protein GLI1Antineoplastic AgentsHedgehog ProteinsProto-Oncogene Proteins c-bcl-2Ubiquitin-Protein LigasesZinc Finger Protein GLI1Bcl-xLbone growthdrug resistanceHedgehogPROTAC

Identifiers

PMID36438482
PMCPMC9691367
OpenAlexW4310461748

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.