Evidence map›Paper›PMID 36438026›Full record

ArticleFrontiers in medicine2022

Characterization of B cells in lupus erythematosus skin biopsies in the context of different immune cell infiltration patterns.

Luka de Vos, Tugce Guel, Dennis Niebel, Sandra Bald, Adrian Ter Steege, Thomas Bieber, Joerg Wenzel

Open access · goldAbstract read
In one paragraph

Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Review
  6. Review
  7. The Integrated Cellular and Molecular Landscape of Autoimmunity.bioRxiv : the preprint server for biology · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Luka de VosDepartment of Dermatology and Allergy, University Hospital Bonn, Bonn, Germany.
Tugce GuelDepartment of Dermatology and Allergy, University Hospital Bonn, Bonn, Germany.
Dennis NiebelDepartment of Dermatology and Allergy, University Hospital Bonn, Bonn, Germany.
Sandra BaldDepartment of Dermatology and Allergy, University Hospital Bonn, Bonn, Germany.
Adrian Ter SteegeDepartment of Dermatology and Allergy, University Hospital Bonn, Bonn, Germany.
Thomas BieberDepartment of Dermatology and Allergy, University Hospital Bonn, Bonn, Germany.
Joerg WenzelDepartment of Dermatology and Allergy, University Hospital Bonn, Bonn, Germany.
University Hospital Bonn · DEUniversity Hospital Regensburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cutaneous lesions in lupus erythematosus (LE) subtypes are heterogenous. In line with the heterogeneity of the clinical presentation, the underlying lesional inflammation in LE skin samples is defined by different immune cell infiltrates. Pathophysiologically, lesional inflammation is driven by autoreactive cytotoxic T cells, targeting keratinocytes; plasmacytoid dendritic cells (pDCs), producing large amounts of interferon (IFN); and B cells, whose function in cutaneous LE is still unclear. This study aims to (a) classify inflammatory patterns with regard to the dominating cell type or cytokine expression and (b) investigating the specific role of B cells in LE skin lesions. Therefore, the immunohistological expression of inflammatory surrogates (CD20, CD123, MXA) in skin samples of

Indexed as

BAFF receptor (BAFF-R)B cellBLyScutaneous lupus erythematosusinflammationinterferonMXApDC

Identifiers

PMID36438026
PMCPMC9685332
OpenAlexW4308662469

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.